Estradiol (Estrogens)

• GnRH - FSH, LH (gonadotropins)

• Ovarian follicles=thecal+granulosa cellsLH - thecal cells --androgens(T) FSH - granulosa cells ---aromatase (T to E2 )

• Negative feedback at Hypo & AP by E2 , Progesterone (P4), inhibin

• Estradiol: many targets & actions

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