Eukaryotic promoters also modular
+1/-1 region Inr region - initiator region
usually ~-25 TATA box - TBP binding site
other elements upstream of TATA box (gc boxes etc)
can have enhancer domains at a greater distance
enhancer domains encode TF binding sites
0%
100%
-100’s
~-25 +1
Effect of mutation at indicated positions on
relative level of gene expression
-70
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