Conserved sequences upstream or gene suggested
important for regulation.
Mutations in this region can affect both the level of gene
expression and whether or not gene is expressed
Only some positions important (e.g. see below)
Relative similarity to consensus allows for 1,000 fold
differences in level of gene expression
0%
100%
-35
-10 +1
Effect of mutation at indicated positions on
relative level of gene expression
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