University of Kentucky - College of Pharmacy  
College of Pharmacy    Chandler Medical Center    Department of Chemistry    University of Kentucky  
Peter A. Crooks, Ph.D.
Department of Pharmaceutical Science
College of Pharmacy
University of Kentucky
907 Rose Street, 501A
Lexington, KY 40536
phone: 859-257-1718
fax: 859-257-7585
 pcrooks@email.uky.edu

Publications:

Original Research Articles Published in Peer-Reviewed Journals

  • “Synthesis of 2-(Pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(Pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(Pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a Class of Potent Nicotinic Acetylcholine Receptor–Ligands”. By Balwinder S. Bhatti, Jon-Paul Strachan, Scott R. Breining, Craig H. Miller, Persida Tahiri, Peter A. Crooks, Niranjan Deo, Cynthia S. Day, and William S. Caldwell, J. Org. Chem., 2008, in press.
  • “Permeability of Microneedle-treated Skin is Increased by Increasing Charge of Naltrexone and Naltrexol In Vitro”. By Stan L. Banks, Harvinder S. Gill, Mark R. Prausnitz, Peter A. Crooks, and Audra L. Stinchcomb, Pharm. Research., 2008, in press.
  • “Effect of Celecoxib and the Novel Anti-cancer Agent Dimethylamino-parthenolide in a Developmental Model of Pancreatic Cancer”. By Michele Yip-Schneider, Huangbing Wu, Victor Njoku, Matthew Ralstin, Bryan Holcomb, Peter Crooks, Sundar Neelakantan, Christopher Sweeney, and C. Max Schmidt, Pancreas, 2008, in press.
  • “CuPy2Cl2: A Novel and Efficient Catalyst for Synthesis of Propargylamines under Conventional Method and Microwave Irradiation”. By J. Venu Madhav, B. Suresh Kuarm, P. Someshwar, B. Rajitha, Y.Thirupathi Reddy and Peter A. Crooks, Synth. Comm., 2008, in press.
  • “Sulfamic Acid: An Efficient, Cost-effective and Reusable Solid Acid Catalyst for the Synthesis of 1, 8-Naphthyridines Under Solvent-free Heating and Microwave Irradiation”. By Y. Thirupathi Reddy, P. Raghotham Reddy, B. Rajitha, M. Nikhil Reddy, and Peter A. Crooks, Synth. Comm., 2008, in press.
  • “Tetrabenzylpyrophosphate: An Efficient Catalyst for the Synthesis of Carboxamides from Carboxylic Acids and Amines”. By Y. Thirapathy Reddy, P. Narsimha Reddy, P. Raghotham Reddy, and Peter A. Crooks, Chem. Lett., 2008, 37(8), xxxx.
  • “In Vivo Evaluation of a Transdermal Codrug of 6-Beta-Naltrexol linked to Hydroxybupropion in Hairless Guinea Pigs”. By Paul K. Kiptoo, Kalpana S. Paudel, Dana C. Hammell, Mohamad O. Hamad, Peter A. Crooks, and Audra L. Stinchcomb, Europ. J. Pharm. Sci., 2008, 33, 371-379.
  • “Effect of Celecoxib and the Novel Anti-cancer Agent LC-1 in a Carcinogen-induced Model of Pancreatic Cancer”. By Michele T. Yip-Schneider, Huangbing Wu, Victor Njoku, Matthew Ralstin, Bryan Holcomb, Peter A. Crooks, Sundar Neelakantan, Christopher J. Sweeney, and C. Max Schmidt, Carcinogenesis, 2008, in press.
  • “Development of a GC-MS Assay for the Determination of Fentanyl Pharmacokinetics in Rabbit Plasma after Sublingual Spray Delivery". By Ahmad Malkawi, Abeer M. Al-Ghananeem, and Peter A. Crooks, AAPS Journal, 2008, in press.
  • “(11R)-13-(4-Hydroxyphenylethylamino)-4,5-epoxy-11,13-dihydrocostunolide”. By Shama Nasim, Sean Parkin and Peter A. Crooks, Acta Crystallogr., Section E, 2008, 64E, o644.
  • “(11R), (13R)-1-aminotetralino)-4,5-epoxy-11,13-dihydrocostunolide”. By Shama Nasim, Sean Parkin and Peter A. Crooks, Acta Crystallogr., Section E, 2008, E64, o639.
  • “The NF-?B Subunit, Rel A, is Associated with In Vitro Survival and Clinical Disease Progression in Chronic Lymphocytic Leukemia and Represents a Promising Therapeutic Target”. By Saman Hewamana, Suhair Alghazal, Thet Thet Lin, Mathew Clement, Chris Jenkins, Monica Guzman, Craig T. Jordan, Sundar Neelakantan, Peter A. Crooks, Alan K. Burnett, Guy Pratt, Chris Fegan, Clare Rowntree, Paul Brennan and Chris Pepper, Blood, 2008, in press.
  • “Extending the Analysis of Nicotinic Receptor Antagonists with the Study of Alpha6 Nicotinic Receptor Subunit Chimeras”. By Roger L. Papke, Linda P. Dwoskin, Clare Stokes, Guangrong Zheng, Zhenfa Zhang, J. Michael McIntosh, and Peter A. Crooks, Neuropharmacology, 2008, in press.
  • “Synthesis and Antitubercular Activity of a Series of Hydrazone and Nitrovinyl Analogs Derived from Heterocyclic Aldehydes”, By Vijayakumar N. Sonar and Peter A. Crooks. J. Enz. Inhibit. Medicin. Chem., 2008, in press.
  • “Ceric Ammonium Nitrate (CAN): An Efficient Catalyst for Coumarin Synthesis via Pechmann Condensation using Conventional Heating and Microwave Irradiation”. By Y. Thirupathi Reddy, Vijayakumar N. Sonar, Peter A. Crooks, Pavan K. Dasari, P. Narsimha Reddy, and B. Rajitha, Synth. Comm., 2008, in press.
  • “Computational Neural Network Analysis of the Affinity of N-n-Alkylnicotinium Salts for the a4ß2* Nicotinic Acetylcholine Receptor”. By Fang Zheng, Chang-Guo Zhan, Linda P. Dwoskin, and Peter A. Crooks, J. Enz. Inhibit. Med. Chem., 2008, in press.
  • “Region-specific Effects of N,N’-Dodecane-1,12-diyl-bis-3-picolinium Dibromide (bPiDDB) on Nicotine-induced Increase in Extracellular Dopamine In Vivo”. By Shafiqur Rahman, Zhenfa Zhang, Roger L. Papke, Peter A. Crooks, Linda P. Dwoskin, and Michael T. Bardo, Brit. J. Pharmacol., 2008, 153, 792-804.
  • "Modern Instrumental Methods for Studying Mechanisms of Toxicology." By Peter A. Crooks, David R. Worthen, J. Donald deBethizy, Gary D. Byrd, and William S. Caldwell, Invited Chapter in: Principles and Methods of Toxicology, Fifth Edition, Ed. A. Wallace Hayes, Taylor & Francis, Philadelphia, 2008, Chapter 41, pp 2041-2112.
  • “Carrrier Mediated Transport at the Blood-Brain Barrier for the Quaternary Ammonium Nicotinic Receptor Antagonist, N, N’-Dodecyl-bis-picolinium bromide (bPiDDB)”. By Paul R. Lockman, Werner J. Geldenhuys, Vamshi Manda, Fancy Thomas, Peter A. Crooks, Linda P. Dwoskin and David D. Allen, J. Pharmacol. Exp. Therap., 2008, 324, 244-250.
  • “3-Ethyl-2-methyl-5-methylene-6,7-dihydroindol -4(5H)-one”. By Vijayakumar N. Sonar, Sean Parkin and Peter A. Crooks, Acta Crystallogr., Section E, 2007, 64, 0158.
  • “A New Polymorph of Oxycodone N-17R-oxide”. By Vijayakumar N. Sonar, Sean Parkin and Peter A. Crooks, Acta Crystallogr., Section C, 2007, accepted for publication subject to revision.
  • “(E)-3-(Benzo[b]thiophen-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile and (Z)-3-(benzo[b]thiophen-2-yl)-2-(3,4-dimethoxyphenyl)acrylonitrile”. By Vijayakumar N. Sonar, Sean Parkin and Peter A. Crooks, Acta Crystallogr., Section C, 2007, C63, o743-o745.
  • “(11R)-13-(Naphthylmethylamino)-4, 5-epoxy-11,13-dihydrocostunolide”. By Shama Nasim, Sean Parkin and Peter A. Crooks, Acta Crystallogr., Section E, 2007, E63, o4274.
  • “Novel substituted (Z)-2-(N-Benzylindol-3-ylmethylene)quinuclidin-3-one & (Z)-(±)-2-(N-Benzylindol-3-ylmethylene)quinuclidin-3-ol Derivatives as Potent Thermal Sensitizing Agents”. By Vijayakumar N. Sonar, Y. Thirupathi Reddy, Konjeti R. Sekhar, Soumya Sasi, Michael L. Freeman, and Peter A. Crooks, Bioorganic and Medicinal Chemistry Letters, 2007, 17, 6821-6824.
  • “tris-Azaaromatic Quaternary Ammonium Salts: Novel Templates as Antagonists at Nicotinic Receptors Mediating Nicotine-Evoked Dopamine Release”. By Guangrong Zheng, Sangeetha P. Sumithran, Agripina G. Deaciuc, Linda P. Dwoskin and Peter A. Crooks, Bioorganic and Medicinal Chemistry Letters, 2007, 17, 6701-6738.
  • “bis-Azaaromatic Quaternary Ammonium Salts as Antagonists at Nicotinic Receptors Mediating Nicotine-Evoked Dopamine Release: An Investigation of Binding Conformation”. By Guangrong Zheng, Zhenfa Zhang, Marharyta Pivavarchyk, Agripina G. Deaciuc, Linda P. Dwoskin and Peter A. Crooks, Bioorganic and Medicinal Chemistry Letters, 2007, 17, 6734-6738.
  • “(Z)-3-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-(3-thienyl)acrylonitrile”. Vijayakumar N. Sonar, Sean Parkin and Peter A. Crooks, Acta Crystallogr., Section E, 2007, E63, o3979.
  • “(11R)-13-(Benzylamino)-4,5-epoxy-11,13-dihydrocostunolide”. By Shama Nasim, Sean Parkin and Peter A. Crooks, Acta Crystallogr., Section E, 2007, E63, o3922.
  • “rac-(Z)-2-(Naphthalen-1-ylmethylene)-1-azabicyclo[2.2.2]octan-3-ol”. By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2007, E63, o3915.
  • “rac-(Z)-2-(2,4-Dichlorobenzylidene)-1-azabicyclo[2.2.2]octan-3-ol”. By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2007, E63, o3907.
  • “An Orally Biovailable Parthenolide Analog Selectively Eradicates Acute Myelogenous Leukemia Stem Cells and Progenitor Cells”. By Monica L. Guzman, Randall M. Rossi, Sundar Neelakantan, Xiaojie Li, Cheryl Corbett, Duane C. Hassane, Michael W. Becker, John M. Bennet, Edmund Sullivan, Joshua L. Lachowicz, Christopher Sweeney, William Matthews, Martin Carroll, Peter A. Crooks, and Craig T. Jordan, Blood, 2007, 110, 4427-4435.
  • “The Radiosensitization Effect of Parthenolide in Prostate Cancer Cells is Mediated by NF-?B Inhibition and Enhanced by the Presence of PTEN”. By Yulan Sun, Daret K. St. Clair, Fang Fang, Graham W. Warren, Vivek M. Rangnekar, Peter A. Crooks, and William H. St. Clair, Molecular Cancer Therapeutics, 2007, 6(9), 2477-2486.
  • "Lobelane Decreases Methamphetamine Self-administration in Rats”. By Nicole M. Neugebauer, Steven B. Harrod, Dustin J. Stairs, Peter A. Crooks, Linda P. Dwoskin, and Michael T. Bardo, European Journal of Pharmacology, 2007, 571, 33-38.
  • “Targeting Reward-Relevant Nicotinic Receptors in the Discovery of Novel Pharmacotherapeutic Agents to Treat Tobacco Dependence”. By Linda P. Dwoskin, Marharyta Pivavarchyk, Barry M. Joyce, Nichole M. Neugebauer, Guangrong Zheng, Zhenfa Zhang, Michael T. Bardo, and Peter A. Crooks, invited chapter, 55th Annual Nebraska Symposium on Motivation: The Motivational Impact of Nicotine and its Role in Tobacco Use. Eds. R.A. Bevins and A.R. Caggiula, Springer, in press, 2007.
  • "An HPLC Method for the Simultaneous Determination of Neurotoxic Dipyridyl Isomers in Human Plasma”. By Ahmad Malkawi, Abeer Al-Ghananeem, Shama Naseem, Xiaochen Wei, Jose de Leon, and Peter A. Crooks, J. Pharm. Biomed. Anal., 2007, 45, 120-124.
  • “Discovery of a Novel Nicotinic Receptor Antagonist for the Treatment of Nicotine Addiction: 1-(3-methylpyridinium)-12-triethylammonium-dodecane Dibromide (TMPD)”. By Linda P. Dwoskin, Barry M. Joyce, Guangrong Zheng, Nichole M. Neugebauer, Vamshi K. manda, Paul Lockman, Roger L. Papke, Michael T. Bardo, and Peter A. Crooks, Biochemical Pharmacology, 2007, 74, 1271-1282.
  • “Methyl 2, 6-Dihydroxy-3-nitrobenzoate”. By Vijayakumar N. Sonar, M. Venkataraj, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2007, E63, o3227.
  • “Benzyl 2, 6-Dihydroxy-3-nitrobenzoate”. By Vijayakumar N. Sonar, M. Venkataraj, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2007, E63, o3226.
  • “The Radiosensitizing Effects of L-Canavanine”. By David R. Worthen and Peter A. Crooks, In: Herbal Drugs: A Twenty-First Century Perspective. Edit. Rajesh Arora, CABI Publishing, UK,2007, in press,.
  • “Effect of Celecoxib and Novel Agent LC-1 in a Hamster Model of Lung Cancer”. By Reid C. Vegeler, Michele T. Yip-Schneider, Matthew Ralstin, Huangbing Wu, Peter A. Crooks, Sundar Neelakantan, Harikrishna Nakshatri, Christopher J. Sweeney, and C. Max Schmidt, Journal of Surgical Research, 2007, 143, 169-176.
  • “(4-Methoxy-3-nitrobenzylidenamino)guanidine Hydrochloride”. By Joshua R. Ring, Sean Parkin and Peter A. Crooks, Acta Crystallogr., Section C, 2007, C63, o392-o394.
  • “Phase I and Phase II Ocular Metabolic Activities and the Role of Metabolism in Ophthalmic Prodrug and Codrug Design and Delivery”. By Abeer M. Al-Ghananeem and Peter A. Crooks, Molecules, 2007, 12, 373-388.
  • “Supression of Pancreatic Tumor Growth by Combination Therapy with Sulindac and LC-1 is Associated with Cyclin D1 Inhibition In Vivo”. By Michele T. Yip-Schneider, Huangbing Wu, Matthew Ralstin, Constantin Yiannoutsos, Peter A. Crooks, Sundar Neelakantan, Steven Noble, Harikrishna Nakshatri, Christopher J. Sweeney, and C. Max Schmidt, Mol. Cancer Therapeutics, 2007, 6(6):1736-1744.
  • “(Z)-2-[(Phenylsulfonyl-1H-indol-3-yl)methylene]-1-azabicyclo[2.2.2]octan-3-one Semicarbazone”. By Vijayakumar N. Sonar, M. Venkataraj, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section C, 2007, C63, o277-o279.
  • “Rac-(Z)-2-Thiophen-2-ylmethylene-1-azabicyclo[2.2.2]octan-3-ol”. By Vijayakumar N. Sonar, M. Venkataraj, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section C, 2007, C63, o493-o495.
  • “(E)-1-(2-Chlorophenyl)methyleneaminoguanidine hydrochloride”. By Vijayakumar N. Sonar, Joshua R. Ring, Maxime Siegler and Peter A. Crooks, Acta Crystallogr., Section E, 2007, E63, o974-o975.
  • "Computational Neural Network Analysis of the Affinity of Lobeline and Tetrabenazine Analogs for the Vesicular Monoamine Transporter-2". By Fang Zheng, Guangrong Zheng, A. Gabriela Deaciuc, Chang-Guo Zhan, Linda P. Dwoskin and Peter A. Crooks, Bioorg. Med. Chem, 2007, 15, 2975-2992.
  • "A Pharmacokinetic Study on 3-(N-Benzylindole-3-yl)methylenequinuclidin-3-ol; a Novel Radiosensitization Agen". By Roger L. Papke, Linda P. Dwoskin, and Peter A. Crooks, J. Neurochemistry, 2007, 101, 160-167.
  • "Effects on Nornicotine Enantiomers on Intravenous S(-)-Nicotine Self-Administration and Cardiovascular Function in Rats". By Dustin J. Stairs, Nicole M. Neugebauer, Xiaochen Wei, C. Boustany, Marhaba Hojahmet, Lisa A. Cassis, Peter A. Crooks, and Linda P. Dwoskin, Michael T. Bardo, Psychopharmacology, 2007, 190, 145-155.
  • "(E)-1-(2-Methoxyphenyl)methylene aminoguanidine monohydrochloride. By Vejayakumar N. Sonar, Sundar Neelakantan, Maxime Siegler and Peter A. Crooks, Acta Crystallogr., Series E, 2007, E63, o535-536.
  • "(Z)-2-(1-Benzyl-5-nitro-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one". By Vijayakumar N. Sonar, Sean Parkin and Peter A. Crooks, Acta Crystallogr. Section E, 2007, C63, o135-o136.
  • "A Pharmacokinetic Study on 3-(N-Benzylindole-3-yl)methylenequinuclidin-3-ol; a Novel Radiosensitization Agent". By Abeer M. Al-Ghananeem, Zaineb Al-Beyati, Ahmad Malkawi, Vijayakumar Sonar, and Peter A. Crooks, Cancer Chemother. Pharmacol., 2007,, 60, 915-919.
  • "Tablet Formulation Studies on Nimesulide- and Meloxican-cyclodextrin Binary systems". Buchi N. Nalluri, K. P. R. Chowdary, K. V. R. Murthy, G. Becket, and Peter A Crooks, AAPS PharmSciTech, 2007, 8(2), Article 36, E1-E7.
  • "A Novel Chemical delivery System Comprising an Ocular Sustained Release Formulation of 3a, 17a, 21-Trihydroxy-5 -pregnan-20-one-BIS-5-fluorouracil Codrug. By Michelle Howard-Sparks, Abeer M. Al-Ghananeem, Andrew P. Pearson, and Peter A. Crooks, Drug Development and Industrial Pharmacy, 2007, 33, 677-682.
  • "Novel Chemical Enhancers of Heat Shock Increase Thermal Radiosensitization Through a Mitotic Catastrophe Pathway". By Konjeti R Sekhar, Vijayakumar N. Sonar, Venkatraj Muthusamy, Soumya Sasi, Andrei Laszlo, Jamil Swani, Nobuo Horikoshi, Ryji Higashikubo, Robert G. Bristow, Michael J. Borrelli, Peter A. Crooks, James R. Lepock, Joseph L. Roti Roti, and Michael L. Freeman, Cancer Res., 2007, 67, 695-701.
  • "The Effects of a Novel Nicotinic Receptor Antagonist N, N-Dodecane-1, 12-diyl-bis-picolinium dibromide (bPiDDB) on Acute and Repeated Nicotine-induced Increases in Extracellular Dopamine in Rat Nucleus Accumbens". By Shafiq Rahman, Nicole M. Neugebauer, Zhenfa Zhang, Peter A. Crooks, Linda P. Dwoskin, and Michael T. Bardo, Neuropharmacology, 2007, 52, 755-763.
  • "Scopolamine Sublingual Spray: An Alternative Route of Delivery". By Abeer Al-Ghananeem, Ahmad H. Malkawi, and Peter A. Crooks, Drug Development and Industrial Pharmacy, 2007, 33, 577-582.
  • "(Z)-2-(4-Methylbenzylidene)-1-azabicyclo[2.2.2]octan-3-one". By Vijayakumar N. Sonar, M. Venkataraj, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62, o5740-o5741.
  • "Modeling Subtype-Selective Agonists Binding with a4ß2 and a7 Nicotinic Acetylcholine Receptors: Effects of Local Binding and Long-Range Electrostatic Interactions". By Xiaoqin Huang, Fang Zheng, Xi Chen, Peter A. Crooks, Linda P. Dwoskin, and Chang-Guo Zhan, J. Medicin. Chem.,2006, 49, 7661-7674.
  • "(Z)-2-Thiophen-2-ylmethylene-1-azabicyclo[2.2.2]octan-3-one". By Vijayakumar N. Sonar, M. Venkataraj, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62, o5869-o5870.
  • "(Z)-2-(2-Methylbenzylidene)-1-azabicyclo[2.2.2]octan-3-one". By Vijayakumar N. Sonar, M. Venkataraj, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62, o5738-o5739.
  • "(Z)-2-(1, 3-Benzodioxol-5-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one". By Vijayakumar N. Sonar, M. Venkataraj, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62, o5742-o5744.
  • "Nornicotine Inhibition of Striatal Dopamine Transporter Function via Nicotinic Receptor Activation". By Lisa S. Middleton, Peter A. Crooks, Peter J. Wedlund, Wayne A. Cass, and Linda P. Dwoskin, Synapse, 2006, 61(3), 157-165.
  • "(Z)-2-(Cyclohexylidene)-1-azabicyclo[2.2.2]octan-3-one". By Vijayakumar N. Sonar, M. Venakataraj, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62, o5576-5577.
  • "Assessment of Nasal Drug Delivery in Humans Using Radionuclide Imaging Techniques". By Abeer M. Al-Ghananeem and Peter A. Crooks, Pharmaceutical Formulation and Quality, 2006, 8(4), 38-43.
  • "1-Azepan-1-yl-2-(1H-indol-3-yl)ethane-1,2-dione". By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62, o3744-o3746.
  • "Des-keto Lobeline Analogs with Increased Potency and Selectivity at Dopamine and Serotonin Transporters". By Guangrong Zheng, David Horton, Agripina G. Deaciuc, Linda P. Dwoskin, and Peter A. Crooks, Bioorganic and Medicinal Chemistry Letters, 2006, 16, 5018-5021.
  • "1-(4-tert-Butylbenzyl)-1H-indole-3-carbaldehyde". By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62, o3380-o3381.
  • "(E)-1-Benzyl-3-(2-nitrovinyl)-1H-indole". By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62, o3328-o3330.
  • "Vesicular Monoamine Transporter 2: Role as a Drug Target for Ligand Development". By Guangrong Zheng, Linda P. Dwoskin, and Peter A. Crooks, AAPS Journal: NIDA -AAPS Symposium on Drugs of Abuse: Mechanisms of Toxicity, Toxicokinetics and Medical Consequences of Drugs of Abuse", 2006, 8(4), Article 78, E682-E692.
  • "1-(4-Methoxybenzyl)-1H-indole-3-carbaldehyde". By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62, o3231-o3232.
  • "Synthesis and Hydrolytic Behavior of Two Novel Carbonate-linked Tripartate Codrugs ofNaltrexone and 6ß-Naltrexol with Hydroxybupropion as Potential Alcohol Abuse and Smoking Cessation Agents". By Mohamed O. Hamad, Paul K. Kiptoo, Audra L. Stinchcomb, Peter A. Crooks, Bioorg. Med. Chem., 2006, 14, 7051-7061.
  • "Opiate Receptor Binding Properties of Morphine-, Dihydromorphine-, and Codeine-6-O-Sulfate Ester Congeners". By Peter A. Crooks, Santosh Kottayil, Abeer M. Al-Ghananeem, Stephen R. Byrn, and D. Alan Butterfield, Bioorg. Med. Chem. Lett., 16, 4291-4295, 2006.
  • "Enhancement of Transdermal Delivery of 6- -Naltrexol via a Codrug Linked to Hydroxybupropion". By Paul K. Kiptoo, Mohamed, O. Hamad, Peter A. Crooks, and Audra L. Stinchcomb, J. Controlled Release, 2006, 113, 137-145.
  • "N, N - Disubstituted Piperazines and Homopiperazines: Synthesis and Affinities at a4b2* and a7* Neuronal Nicotinic Acetylcholine Receptors". By Jianhong Chen, Agripina G.Deaciuc, Linda P. Dwoskin, Donglu Bai and Peter A. Crooks, J. Enz. Inhibit. Med. Chem., 2006, 21(6), 667-680.
  • "Methyl (E)-2-cyano-3-(1H-indol-3-yl)acrylate". By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62, o1077-o1078.
  • "1-(1H-Indol-3-ylcarbonyl)-N-(4-methoxybenzyl)-formamide". By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section C, 2006, C62, o153-o154.
  • "(Z)-2-[1-(4-Methylbenzenesulfonyl)-1H-indol-3-ylmethylene]-1- azabicyclo[2.2.2]octan-3-one" By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62, o623-o625.
  • "Oxycodone via Sublingual Spray for Acute Pain Management". By Abeer M. Al-Ghananeem, Ahmad Malkawi, and Peter A. Crooks, AAPS Journal, 2006, 7(1), Article 23.
  • "(Z)-2-(4-Methoxy-benzylidene)-1-azabicyclo[2.2.2]octan-3-one". By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62, o396-o397.
  • "(Z)-2-(2-Methoxy-benzylidene)-1-azabicyclo[2.2.2]octan-3-one". By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2006, E62, o393-o395.
  • "Synthesis and Stability of Two Indomethacin Prodrugs". By Shyamala Chandrasekaran, Abeer M. Al-Ghananeem, Robert M. Riggs, and Peter A. Crooks, Biorg. Med. Chem. Lett., 2006, 16, 1874-1879.
  • " N-Alkylnicotinium Analogs, a Novel Class of Antagonists at a4ß2* Nicotinic Acetylcholine Receptors: Inhibition of Nicotine-Evoked 86Rb+ Efflux from Rat Thalamic Synaptosomes " . By Lincoln H. Wilkins jr., Dennis K. Miller, Joshua T. Ayers, Peter A. Crooks, and Linda P. Dwoskin, AAPS Journal: AAPS-NIDA Symposium, Frontiers in Science: Drug Addiction: From Basic Research to Therapeutics, 2006, 7(4), Article 90, E922-E930.
  • " Effect of a Novel Nicotinic Receptor Antagonist, N,N’-dodecane-1,12-diyl-bis-picolinium dibromide (bPiDDB), on Nicotine Self-Administration and Hyperactivity in Rats " . By Nicole M. Neugebauer, Zhenfa Zhang, Peter A. Crooks, Linda P. Dwoskin and Michael T. Bardo, Psychopharmacology., 2006, 184, 426-434.
  • "QSAR Modeling of mono- and bis-Quaternary Ammonium Salts that Act as Antagonists at Neuronal Nicotinic Acetylcholine Receptors Mediating Dopamine Release", by Fang Zheng, Bayram, Sangeetha P. Sumithran, Joshua T. Ayers, Chang-Guo Zhan, Jeffrey D. Schmitt, Linda P. Dwoskin, and Peter A. Crooks, Bioorg. Med. Chem. , 2006, 16, 1874-1879.
  • " Synthesis and Evaluation of a Series of Tropane Analogues as Novel Vesicular Monoamine Transporter-2 Ligands " . By Guangrong Zheng, Linda P. Dwoskin, Agripina G. Deaciuc, and Peter A. Crooks, Bioorg. Med. Chem. Lett., 2005, 15, 4463-4466.
  • "(2E, 4E)-8-Methyl-2, 4-bis-thiophen-3-ylmethylene-8-azabicyclo[3.2.1]octan-3-one". By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2005, E61, o3445-o3446.
  • " (Z)-2-(3-Methoxybenzylidene)-1-azabicyclo[2.2.2]octan-3-one " . By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section C, 2005, C61, o660-0661.
  • "Modeling Multiple Structures of Nicotine and Deschloroepibatidine Interacting with a4ß2 Nicotinic Acetylcholine Receptors: From Microscopic binding to Phenomenological Binding Affinity". By Xiaoqin Huang, Fang Zheng, Peter A. Crooks, Linda P. Dwoskin and Chang-Guo Zhan, J. Amer. Chem. Soc., 2005, 127, 14401-14414.
  • " Transdermal Delivery of Naltrexone and its Active Metabolite 6-beta-Naltrexol in Human Skin In Vitro and Guinea Pigs In Vivo " . By Kalpana S. Paudel, Nalluri B Naidu, Paul Kiptoo, Dana Hammell, Mohamed Hamad, Satyanarayana Valiveti, Peter A. Crooks, and Audra L. Stinchcomb, J. Pharm. Sci. , 2005, 94, 1965-1975.
  • " Defunctionalized Lobeline Analogues: Structure-Activity of Novel Ligands for the Vesicular Monoaminr Transporter " . By Guangrong Zheng, Linda P. Dwoskin, A. Gabrielle Deaciuc, Seth D. Norrholm, and Peter A. Crooks, J. Medicin. Chem., 2005, 48, 5557-5560.
  • " Evaluation of O3?-, O21-DI-(N1-Methyloxycarbonyl-2, 4-dioxo-5-fluoropyrimidinyl)17?-hydroxy-5?- pregnan-20-one as a Novel Potential Antiangiogenic Codrug " . By Michelle Howard-Sparks, Abeer M. Al-Ghananeem, Andrew P. Pearson, and Peter A. Crooks, J. Enzyme Inhibit. Med. Chem., 2005, 20, 417-428.
  • " The Characterization of a Novel a7-selective nAChR Agonist and the Modulation of Agonist Properties by Boron Inclusion " . By Roger L. Papke, Linda Dwoskin, Nicole A. Horenstein, and Peter A. Crooks, Bioorg. Med. Chem. Lett. ., 2005, 15, 3874-3880.
  • " Introduction of Unsaturation into the N-n-Alkyl Chain in the neuronal Nicotinic Receptor Antagonists, NONI and NDNI: Effect on Affinity and Selectivity " . By Sangeetha P. Sumithran, Peter A. Crooks, Rui Xu, Jun Zhu, Agripina G. Deaciuc, Lincoln H. Wilkins, and Linda P. Dwoskin, AAPS Journal: AAPS-NIDA Symposium, Frontiers in Science: Drug Addiction: From Basic Research to Therapeutics., 2005, 7(1), E201-217.
  • " Molecular Modeling of Mono- and Bis-Quaternary Ammonium Salts as Ligands at the a4ß2* Nicotinic Acetylcholine Receptor Subtype Using Non-Linear Techniques". By Joshua T. Ayers, Aaron Clauser, Jeffrey D. Schmitt, Linda P. Dwoskin and Peter A. Crooks, AAPS Journal: AAPS-NIDA Symposium, Frontiers in Science: Drug Addiction: From Basic Research to Therapeutics., 2005, 7(3), E678-E685.
  • " In Vitro Release Studies on Matrix Type Transdermal Drug Delivery Systems of Naltrexone and its Acetyl Prodrug " . Buchi N. Nalluri, Caitlin Milligan, Jianhong Chen, Peter A. Crooks, and Audra L. Stinchcomb, Drug Development and Industrial Pharmacy. , 2005, 31, 871-877.
  • " A General Procedure for the Enantioselective Synthesis of the CNS-active Minor Tobacco Alkaloids: Nornicotine, Anabasine and Anatabine " . by Joshua T. Ayers, Rui Xu, Linda P. Dwoskin, and Peter A. Crooksi, AAPS Journal: AAPS-NIDA Symposium, Frontiers in Science: Drug Addiction: From Basic Research to Therapeutics , 2005, 7(3), E752-E758.
  • " A 1R, 2R, 5R-(+)-2a-hydroxypinanone Ketimine " . By Joshua T. Ayers, Vijayakumar N. Sonar, Sean Parkin, Linda Dwoskin, and Peter A. Crooks, Acta Crystallogr., Section E., 2005, E61, o2682-o2684.
  • " (E)-2-Methyl-3-(2-methyl-2-nitrovinyl)-1H-indole and (E)-3-(2-Methyl-2-nitrovinyl)-2-phenyl-1H-indole " . By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section C., 2005, C61, o527-o530.
  • " 6-Acetoxy-4,5-epoxy-3-methoxy-17-methyl-morphin-7-ene " . By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E., 2005, E61, o2579-2581.
  • " (E)-N-(2,5-Dichlorophenyl)-N-thiophen-3-ylmethylene-hydrazine " . By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E., 2005, E61, 01907-o1909.
  • " Novel Antiglaucoma Prodrugs and Codrugs of Ethacrynic Acid " . By Grazyna Cynkowska, Tadeusz Cynkowski, Abeer A. Al-Ghananeem, Hong Guo, Paul Ashton, and Peter A. Crooks, Bioorg. Med. Chem. Lett. ., 2005, 15, 3524-3527.
  • " Lobeline Analogues as Novel Ligands for the Vesicular Monoamine Transporter " . By Guangrong Zheng, Linda P. Dwoskin, Agripina G. Deaciuc, Seth D. Norholm, Marlon D. Jones, and Peter A. Crooks, Bioorganic Med. Chem., 2005, 13, 3899-3909.
  • " In Vitro/In Vivo Correlation of Transdermal Naltrexone Prodrugs in Hairless Guinea Pigs " . By Satyanarayana Valiveti, Kalpana S. Paudel, Dana C. Hammell, Mohamed O. Hamad, Jianhong Chen, Peter A. Crooks, and Audra L. Stinchcomb, Pharm. Research. ., 2005, 22, 981-989.
  • " 3D-QSAR Study of bis-Azaaromatic Quaternary Ammonium Analogs at the Blood-Brain Barrier Choline Transporter " . By Werner J. Geldenhuys, Paul R. Lockman, Tiffany H. Nguyen, Cornelis J. Van der Schyf, Peter A. Crooks, Linda P. Dwoskin, and David D. Allen, Biorg. Med. Chem., 2005, 13, 4253-4261.
  • " Human Skin Permeation of Branched Chain 3-O-Alkyl Ester and Carbonate Prodrugs of Naltrexone". By Haranath K. Vaddi, Mohamed O. Hamad, Jianhong Chen, Stan L. Banks, Peter A. Crooks, and Audra L. Stinchcomb, Pharm. Research. ., 2005, 22, 758-765.
  • " (Z)-2-Thiophen-3-yl-3-(3,4,5-trimethoxy-phenyl)-acrylonitrile " . By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E., 2005, E61, 933-935.
  • " Bioconversion of Naltrexone and Its 3-O-Alkyl Ester Prodrugs in a Human Skin Equivalent " . By Dana C. Hammell, Elzbieta I. Stolarczyk, Mitch Klausner, Mohamed O. Hamad, Peter A. Crooks, and Audra Stinchcomb, J. Pharm. Sci. ., 2005, 94, 828-826.
  • " In Vivo Evaluation of 3-O-Alkyl Ester Transdermal Prodrugs of Naltrexone in Hairless Guinea Pigs " . By Satyanarayana Valiveti, Dana C. Hammell, Kalpana S. Paudel, Mohamed O. Hamad, Peter A. Crooks, and Audra L. Stinchcomb, J. Controlled Release., 2005, 102, 509-520.
  • " (Z)-3-(1H-Indol-3-yl)-2-thiophen-3-yl-acrylonitrile and (Z)-3-[1-(4-tert-Butyl-benzyl)-1H-indol-3-yl]-2-thiophen-3-yl-acrylonitrile " . By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section C., 2005, C61, 78-80.
  • " Indirect Trapping of the Retro-Conjugate Addition Reaction Intermediate Involved in Lobeline Epimerization: Application to the Synthesis of (-)-Sedamine " . By Guangrong Zheng, Linda P. Dwoskin, and Peter A. Crooks, J. Org. Chem., 2004, 69, 8514-8517.
  • " 4-Benzo[b]thiophen-3-yl-1-methyl-piperidine-4-carbonitrile " . By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E., 2004, E60, 1533-1534.
  • " (Z)-2-(1-Benzenesulfonyl-1H-indol-3-ylmethylene)-1-aza-bicyclo[2.2.2]octan-3-one and (±)-(Z)-2-(1-Benzenesulfonyl-1H-indol-3-ylmethylene)-1-aza-bicyclo[2.2.2]octan-3-ol " . By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Act Crystallogr., Section C., 2004, C60, 659-661.
  • " (E)-N-Benzo[b]thiophen-3-ylmethylene-N-(2,5-dichloro-phenyl)hydrazine " . By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section C., 2004, C60, 550-551.
  • " 1-(2,5-Dichloro-phenyl)-3-methyl-5-phenyl-1H-pyrazole " . By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section C., 2004, C60, 547-549.
  • " Lobeline Analogs with Enhanced Affinity and Selectivity for Plasmalemma and Vesicular Monoamine Transporters and Diminished Activity at ?4?2 and ?7 nAChRs " . By Dennis K. Miller, Peter A. Crooks, Guangrong Zheng, Vladimir P. Grinevich, Seth Norrholm, and Linda P. Dwoskin, J. Pharmacol. Exper. Therap., 2004, 310, 1035-1045.
  • " Physicochemical Evaluation, In Vitro Human Skin Diffusion and Concurrent Biotransformation of O-3-Alkylcarbonate Prodrugs of Naltrexone " . By Omathanu Pillai, Mohamed O. Hamad, Peter A. Crooks, and Audra L. Stinchcomb. Pharm. Research., 2004, 21, 1146-1152.
  • " A Duplex " Gemini &rdquo Prodrug of Naltrexone for Transdermal Delivery &rdquo . By Dana C. Hammell, Mohamed Hamad, H. Kumar Vaddi, Peter A. Crooks, and Audra L. Stinchcomb, J. Controlled Release., 2004, 97, 283-290.
  • " (Z)-3-(1-Methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile " . By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section C., 2004, C60, o217-o218.
  • " Molecular Pathway for Thymoquinone-Induced Cell Cycle Arrest and Apoptosis in Neoplastic Keratinocytes " . By Hala U. Gali-Muhtasib, Wassim G. Abou Kheir, Lynn A. Kheir, and Peter A. Crooks, Anticancer Drugs., 2004, 15(40), 389-399.
  • " 2-(1-Methyl-1H-indol-3ylmethylene)-1-aza-bicyclo[2.2.2]octane-3-one: Acid-Catalyzed Isomerization of the Z isomer to the E isomer " . By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, J. Chem. Crystallogr. ., 2004, 34, 239-244.
  • " Elimination of Alkaloids from Plant-Derived Human Monoclonal Antibody " . By Kisung Ko, Xiaochen Wei, Peter A. Crooks, Hilary Koprowski, Journal of Immunological Methods., 2004, 286, 79-8.
  • " Two isomers of 2,4-dibenzyl-8-azabicyclo[3.2.1]octane-3-ol " . By Guangrong Zheng, Sean Parkin, Linda P. Dwoskin and Peter A. Crooks, Acta Crystallogr., Section C., 2004, C60, o9-o11.
  • " (Z)-2-(1H-Indol-3-ylmethylene)-1-aza-bicyclo[2.2.2]octan-3-one " . By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section C., 2004, C60, o6-o8.
  • " Development of Subtype-Selective Ligands as Antagonists at Nicotinic Receptors Mediating Nicotine-Evoked Dopamine Release. " By Peter A. Crooks, Joshua T. Ayers, Xu Rui, Sangeetha P. Sumithran, Vladimir P. Grinevich, Lincoln Wilkins, A. Gabriela Deaciuc, David D. Allen and Linda P. Dwoskin, Bioorg. Med. Chem. Lett. , 2004, 14, 1869-1874.
  • " Subtype-Selective Nicotinic Receptor Antagonists: Potential as Tobacco Use Cessation Agents. " By Linda P. Dwoskin*, Sangeetha Sumithran, Jun Zhu, A. Gabriela Deaciuc, Joshua T. Ayers and Peter A. Crooks, Bioorg. Med. Chem. Lett. ., 2004, 14, 1863-1867.
  • " Toxicity of Dipyridyl Compounds. " By Shenggang Li, Peter A. Crooks, Xiaochen Wei, and Jose de Leon, Crit. Rev. Tox. ., 2004, 34, 447-460.
  • " The Preparation of 2-Arylmethylidene-8-methyl-8-azabicyclo[3.2.1]octane-3-ones " . By Guangrong Zheng, Linda P. Dwoskin, and Peter A. Crooks, Synth. Comm. , 2004, 34 (11), 1931-1942.
  • " (Z)-2-(2,4-Dimethoxybenzylidene)-1-aza-bicyclo[2.2.2]octan-3-ol " . By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2003, E59, o2010-o2012.
  • " (Z)-2-Benzo[b]thiophen-3-ylmethylene-1-aza-bicyclo[2.2.2]-octan-3-one " . By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2003, E59, o1726-o1728.
  • " (Z)-2-(3-Hydroxy-4-methoxybenzylidene)-1-aza-bicyclo[2.2.2]octane-3-one " . By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section , 2003, C59, o647-o649.
  • " (Z)-2-Thiophen-3-ylmethylene-1-aza-bicyclo[2.2.2]octan-3-one " . By Vijayakumar N. Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr., Section E, 2003, E59, o1464- o1466.
  • " N-n-Alkylnicotinium and N-n-Alkylpyridinium Analogs Inhibit Dopamine Transporter Function: Selectivity as nicotinic Receptor Antagonists " . By Jun Zhu, Peter A. Crooks, Joshua T. Ayers, Sangitha P. Sumithran, and Linda P. Dwoskin, Drug Develop. Res. , 2003, 60, 270-284.
  • " Spectroscopic and Steady-State Kinetic Analysis of the Biosynthetic Arginine Decarboxylase of Yersinia Pestis Utilizing Arginine Analogs as Inhibitors and Alternate Substrates " . By Paul B. Balbo, Chandra N. Patel, R. Scott Adcock, Sundar Neelakantan, Peter A. Crooks, and Marcos A. Oliveira, Biochemistry,, 2003, 42, 15189-15196.
  • " 2-(1-Benzyl-1H-indol-3-ylmethylene)-1-aza-bicyclo[2.2.2]octan-3-one " . By Vijayakumar Sonar, Sean Parkin, and Peter A. Crooks, Acta Crystallogr. Section E, 2003, E59, o1478-o1480.
  • " NADPH Oxidase Activity is Essential for Keap1-Nrf2-Mediated Induction of GCLC in Response to 2-Indole-3-yl-methylenequinuclidin-3-ols " . By Konjeti R. Sekhar, Peter A. Crooks, Vijayakumar N. Sonar, David B. Friedman, Jeff Y. Chan, Michael J. Meredith, Joseph H. Starnes, Kathy R. Kelton, Samantha R. Summar, Soumya Sasi, and Michael Freeman, Cancer Research, 2003, 63, 5636-5645.
  • " An Improved Synthesis of ?-Nicotyrine from the Dehydrogenation of Nicotine: Comparison of Conventional and Microwave-Assisted Reactions. " By Xiaochen Wei and Peter A. Crooks, Synthetic Communications,2003, 33 (19), 3305-3315.
  • " N-n-Alkylpyridinium Analogs, a Novel Class of Nicotinic Receptor Antagonists: Selective Inhibition of Nicotine-Evoked [3H]Dopamine Overflow from Rat Striatal Slices. " By Vladimir P. Grinevich, Peter A. Crooks, Aaron J. Haubner, Omar H. Ghosheh, Joshua T Ayers, and Linda P. Dwoskin, J. Pharmacol. Exp. Ther. , 2003, 306, 1011-1020.
  • " The Mechanism of L-Canavanine Cytotoxicity: Arginyl-tRNA Synthetase as a Novel Target for Anticancer Drug Discovery. " By Aimee K. Bence and Peter A. Crooks, J. Enz. Inhibit. Med. Chem., 2003, 18, 383-394.
  • " An In Vivo Evaluation of the Antiseizure Activity and Acute Neurotoxicity of Agmatine. " By Aimee K. Bence, David R. Worthen, James P. Stables and Peter A. Crooks, Pharmacol. Biochem. Behav. , 2003, 74, 771-775.
  • " Active Transport of High Affinity Choline and Nicotine Analogs into the Central Nervous System by the Blood-Brain Barrier Choline Transporter " . By David D. Allen, Paul R. Lockman, Karen E. Roder, Linda P. Dwoskin and Peter A. Crooks, J. Pharmacol. Exp. Therap., 2003, 304, 1268-1274.
  • " N,N-Disubstituted Piperazines: Synthesis and Affinities at a4b2* and a7* Neuronal Nicotinic Acetylcholine Receptors " . By Jianhong Chen, Seth Norrholm, Linda P. Dwoskin, Peter A. Crooks, and Donglu Bai, Bioorganic and Medicinal Chemistry Letters, 2003, 13, 97-100.
  • " Drug Targeting to the Lung: Chemical and Biochemical Considerations " . By Peter A. Crooks and Abeer M. Al-Ghananeem, invited chapter in &rdquo Pharmaceutical Inhalation Aerosol Technology. Second Edition &rdquo , Edit. Anthony Hickey, Marcel Dekker, Inc., NY, Chapter 4, pp 89 -154, 2003.
  • " N-n-Alkylnicotinium Analogs, a Novel Class of Nicotinic Receptor Antagonists:Interaction with ?4?2* and ?7* Neuronal Nicotinic Receptors " . By Lincoln H. Wilkins, Peter A. Crooks, and Linda P Dwoskin, J. Pharmacol. Exp. Therap., 2003, 304, 400-410.
  • " A Pilot Study of Plasma Caffeine Concentrations in a U.S. Sample of Smokers and Nonsmokers " . By Jose de Leon, Francisco Diaz, Thea Rogers, Debra Browne, Lori Dinsmore, Omar H. Ghosheh, Linda P. Dwoskin, and Peter A. Crooks, Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2003, 27, 165-171.
  • " Plasma cotinine, 3’-hydroxycotinine and their glucuronides in Caucasian and African American smokers " . By Jose de Leon, Francisco J. Diaz, Thea Rogers, Debra Browne, Lori Dinsmore, Omar A. Ghosheh, Linda P. Dwoskin, and Peter A. Crooks, J. Clin. Psychopharmacol. , 2003, 23 (2), 209-211.
  • " L-Canavanine as a Radiosensitization Agent for Human Pancreatic Cancer Cells. " By Aimee K. Bence, Val R. Adams, and Peter A. Crooks, Mol. Cell. Biochem., 2003, 244, 37-43.
  • " The Bis-picolinium Salt, bPiDDB, is a Potent and Selective Antagonist at Nicotinic Acetylcholine Receptors Mediating Nicotine-evoked Dopamine Release in Rat Striatum " . By Peter A. Crooks, Joshua T. Ayers, Aaron J. Haubner, Vladimir P. Grinevich, Sangeetha P. Sumithran, A. Gabriela Deaciuc and Linda P. Dwoskin. Drug and Alcoho Dependence, 2002, 64, 38.
  • " 8-Hydroxyl Esterification of Lobeline Increases Selectivity for the alpha4beta2* Subtype of Nicotinic Receptor, While Increasing Affinity for Dopamine and Serotonin Transporters " . By Seth D. Norrholm, Dennis K. Miller, Marhaba Hojahmat, Peter A. Crooks, and Linda P. Dwoskin. Drug and Alcohol Dependence, 2002, 64, 25.
  • " Meso-transdiene, a Potent, Selective Antagonist at alpha3*-containing Nicotinic Receptors " . By Linda P. Dwowskin, Dennis K. Miller, Guangrong Zheng, Seth D. Norrholm, Vladimir P. Grinevich, and Peter A. Crooks, Drug and Alcohol Dependence, 2002, 64, 38.
  • " bis-Azaaromatic Quaternary Ammonium Analogues: Ligands for ?4?2* and a7* Subtypes of Neuronal Nicotinic Receptors " . By Joshua T. Ayers, Linda P. Dwoskin, A. Gabriela Deaciuc, Vladimir P. Grinevich, Jun Zhu, and Peter A. Crooks, Bioorg. Med. Lett. , 2002, 12, 3067-3071.
  • " Epilepsy - A Review of the Recent Patent Literature " . By Peter A. Crooks, Joshua Ring, and Aaron Haubner, IDrugs, 2002, 5, 990-999.
  • " Synthesis and Evaluation of Conformationally Restricted Pyridino N-Alkylated Nicotine Analogs as Neuronal Nicotinic Acetylcholine Receptor Antagonists " . By Rui Xu, Linda P. Dwoskin, Vladimir P. Grinevich, Aaron Haubner, and Peter A. Crooks, Drug Develop. Res. , 2002, 55, 173-186.
  • " N-n-Alkylnicotinium Analogs, a Novel Class of Nicotinic Receptor Antagonist: Inhibition of S(-) Nicotine-Evoked [3H]Dopamine Overflow from Superfused Rat Striatal Slices " . By Lincoln H. Wilkins, jr., Aaron Haubner, Joshua T. Ayers, Peter A. Crooks, and Linda P Dwoskin, J. Pharmacol. Exp. Therap., 2002, 301, 1088-1096.
  • " The Antiproliferative and Immunotoxic Effects of L-Canavanine and L-Canaline " . By Aimee K. Bence, David R. Worthen, Val R. Adams, and Peter A. Crooks, Anti-Cancer_Drugs, 2002, 13, 313-320.
  • " Synthesis of Endo-12-aminotricyclo[6.3.2.02,7]trideca-2(7),3,5-triene-12-exo-carboxylic Acid: A Novel, Conformationally Restricted Phenylalanine Analogue. " By Peter A. Crooks and Jyothi Matheru, Synth. Comm. , 2002, 32 (24), 3813-3819.
  • " Total Cotinine in Plasma: A Stable Biomarker for Exposure to Tobacco Smoke in Both Smokers and Passive Smokers " . By Jose de Leon, Francesco Diaz, Thea Rogers, D. Brone, L. Dinsmore, Omar A. Ghosheh, Linda P. Dwoskin, and Peter Crooks, J. Clin. Psychopharmacol. , 2002, 22(5), 496-501.
  • " Synthesis of L-Indospicine. " By Aimee K. Bence and Peter A. Crooks, Synth. Commun. , 2002, 32 (13), 2075-2082.
  • " A Novel Mechanism and Potential Use for Lobeline as a Treatment for Psychostimulant Abuse " By Linda P. Dwoskin and Peter A. Crooks, invited review, Biochem. Pharmacol. , 2002, 63, 89-98.
  • " Pharmacological Differences Between Immunoisolated Native Brain and Heterologously Expressed Rat ?4?2 Nicotinic Receptors. " By Anthony Truong, Xiaolei Xing, John R. Forsayeth, Linda P. Dwoskin, Peter A. Crooks, and Bruce N. Cohen, Mol. Brain Res. , 2001, 96, 68-76.
  • " N-n-Alkylnicotinium and N-n-Alkylpyridinium Analogs Inhibit [3H]Dopamine Uptake into Rat Striatal Synaptosomes " . By Jun Zhu, Joshua T. Ayers, Omar Ghosheh, Peter A. Crooks, and Linda P. Dwoskin. Drug and Alcohol Dependence, 2001, 63 (Supplement 1), 177.
  • " Defunctionalized Structural Analogs of Alpha-Lobeline Inhibit [3H]Dopamine Uptake into Rat Striatal Synaptosomes " . By Steven B. Harrod, Peter A. Crooks, Marlon D. Jones, and Linda P. Dwoskin, Drug and Alcohol Dependence, 2001, 63 (Supplement 1), 63.
  • " Nicotinic Acetylcholine Receptor Affinities of Boron-Containing Nicotine Analogs " . By Peter A. Crooks, Rui Xu, Linda P. Dwoskin, Vladimir P. Grinevich,and Gabriela Deaciuc, Drug and Alcohol Dependence, 2001, 63 (Supplement 1), 35.
  • " Nornicotine, a Nicotine metabolite and Tobacco Alkaloid: Desensitization of Nicotinic Receptor-Stimulated Dopamine Release from Rat Striatum " . By Linda P. Dwoskin, LiHong Teng, and Peter A. Crooks, Europ. J. Pharmacol. , 2001, 428, 69-79.
  • " A Contributory Role for Nornicotine in Nicotine Neuropharmacology: Nornicotine Evokes [3H]Dopamine Overflow from Rat Nucleus Accumbens Slices " . By Thomas A. Green, Peter A. Crooks, Michael T. Bardo, and Linda P. Dwoskin, Biochem. Pharmacol. , 2001, 62, 1597-1603.
  • " Synthesis and Binding Affinity of Boron-containing Nicotine Analogs to Nicotinic Acetylcholine Receptors " . Rui Xu, Vladimir P. Grinevich, Gabriela Deaciuc, Linda P. Dwoskin, and Peter A. Crooks. Biorg. Med. Chem. Lett. , 2001, 11, 1245-1248.
  • " Lobeline Attenuates d-Methamphetamine Self-administration in Rats " . By Steven B. Harrod, Linda P. Dwoskin, Peter A. Crooks, Jennifer E. Klebaur, and Michael T. Bardo, J. Pharmacol. Exp. Therap., 2001, 298, 172-179.
  • " Competitive Neuronal Nicotinic Receptor Antagonists: A New Direction for Drug Discovery " . By Linda P. Dwoskin and Peter A. Crooks, J. Pharmacol. Exp. Ther. , 2001, 298, 395-402.
  • " Once Weekly Administration of Nicotine Produces Long-Lasting Locomotor Sensitization in Rats Via a Nicotinic Receptor-mediated Mechanism " . By Dennis K. Miller, Lincoln H. Wilkins, Michael T. Bardo, Peter A. Crooks, and Linda P. Dwoskin, Psychopharmacology, 2001, 156, 469-476.
  • " Accummulation of Nicotine and its Metabolites in Rat Brain after Intermittent or Continuous Peripheral Administration of [2'-14C]-Nicotine " . By Omar A. Ghosheh, Linda P. Dwoskin, Dennis K. Miller, and Peter A. Crooks, Drug Metab. Disposit. , 2001, 29, 645-651.
  • " Lobeline Inhibits the Neuronal and Behavioral Effects of Amphetamine " . By Dennis K. Miller, Peter A. Crooks, LiHong Teng, Jeffrey M. Witkin, Patrik Munzar, Steven R. Goldberg, Jane B. Acri, and Linda P. Dwoskin, J. Pharmacol. Exp. Ther. , 2001, 296, 1023-1034.
  • " Endogenous Indoles as Novel Polyamine Site Ligands at the N-Methyl-D-aspartate Receptor Complex " . By David R. Worthen, David A. Gibson, Dennis T. Rogers, Aimee K. Bence, May Fu, John M. Littleton, and Peter A. Crooks, Brain Research, 2001, 890, 343-346.
  • " Dapsone Analogs as Potential Polyamine Binding Site Modulaters of the N-Methyl-D- Aspartate Receptor Complex " . By Aimee K. Bence, Dennis T. Rogers, David R. Worthen, May Fu, John M. Littleton, and Peter A. Crooks, Drug Develop. Res. , 2000, 51, 268-272.
  • " Rigid Nicotine Analogs Provide Selectivity for ?7 Subunit-Containing Neuronal Nicotinic Acetylcholine Receptors " . Vladimir P. Grinevich, Rui Xu, Peter A. Crooks, Aaron J. Haubner, Roger Papke, and Linda P. Dwoskin, Drug and Alcohol Dependence, 2000, 60 (Supplement), 80-81.
  • " Conformationally Restrained Analogues of NONI and NDNI are Selective Antagonists at the Putative ?3?2 Nicotinic Acetylcholine Receptor (AChR) Subtype " . By Peter A. Crooks, Rui Xu, Vladimir P. Grinevich, Aaron J. Haubner, and Linda P. Dwoskin, Drug and Alcohol Dependence, 2000, 60 (Supplement), 46-47.
  • " Effects of Lobeline on Methamphetamine and Nicotine-Induced Hyperactivity and Sensitization " . By Dennis K. Miller, Thomas A. Green, Steven B. Harrod, Micheal T. Bardo, Peter A. Crooks, and Linda P. Dwoskin, Drug and Alcohol Dependence , 2000, 60, (Supplement), 151-152.
  • " Lobeline Noncompetitively Inhibits Methamphetamine Self-administration in Rats " . By Steven B. Harrod, Jennifer E. Klebaur, Peter A. Crooks, Linda P. Dwoskin, and Michael T. Bardo, Drug and Alcohol Dependence , 2000, 60 (Supplement), 85-86.
  • " Aminoanthroquinones as Novel Ligands on the Polyamine Binding Site of the N-methyl-D-Aspartate Receptor Complex " . By Aimee K. Bence, Dennis T. Rogers, David R. Worthen, May Fu, John Littleton, and Peter A. Crooks, Bioorganic and Medicinal Chemistry Letters, 2000, 10, 2621-2623.
  • " Lobeline Inhibits Nicotine-Evoked [3H]Dopamine Overflow from Rat Striatal Slices and Nicotine-Evoked 86Rb+ Efflux from Thalamic Synaptosomes " . By Dennis K. Miller, Peter Crooks, and Linda P. Dwoskin, Neuropharmacology, 2000, 39, 2654-2662.
  • " Cooperative Effects of Functional Groups in Ester Hydrolysis: Competitive Inhibitory Effect of External Nucleophile Concentration on Intramolecular O- to N-Acylation in O-Acetylsalicylamide " . By Anwar A. Hussain, Janan Jona, and Peter A. Crooks, AAPS Pharm. Sci. Tech. , 2000, 1(3) Article 25.
  • " Recent Developments in Neuronal Nicotinic Acetylcholine Receptor Antagonists " . By Linda P. Dwoskin, Xu Rui, Joshua Ayers, and Peter A. Crooks, Exp. Opin. Ther. Patents, 2000, 10, 1561-1581.
  • " Nornicotine Pretreatment Decreases Intravenous Nicotine Self-Administration in Rats " . By Thomas A. Green, S. B. Phillips, Peter A. Crooks, Linda P. Dwoskin, and Michael T. Bardo, Psychopharmacology, 2000, 152, 289-294.
  • " A Simple High Performance Liquid Chromatographic Method for the Quantification of Total Cotinine, Total 3'-Hydroxycotinine, and Caffeine in the Plasma of Smokers. " By Omar A. Ghosheh, Debra Browne, Thea Rogers, Jose de Leon, Linda P. Dwoskin, and Peter A. Crooks, Journal of Pharmaceutical and Biomedical Analysis, 2000, 23, 543-549.
  • " Direct Determination of Nicotine-N-Glucuronide in Human Biological Samples. " By Gary D. Byrd, William S. Caldwell, Peter A. Crooks, Alain Ravard, and Balwinder S. Bhatti, Drug Metab. Drug Interact. , 2000, 16, 281-297.
  • " Modern Instrumental Methods for Studying Mechanisms of Toxicity " . By William S. Caldwell, J. Donald deBethizy, Peter A. Crooks and Gary D. Byrd, invited chapter in: Principles and Methods of Toxicology, Fourth Edition, Edit. A. Wallace Hayes, Chapter 36, Taylor and Francis, Philadelphia, pp 1689-1757, 2000.
  • " Pharmacological Differences Between MAB-299-Precipitated Rat Brain and ?4?2 Nicotinic Receptors " . By Navid Shafaee, Nareerat Viseshakul, McCann Houng, Linda P. Dwoskin, Peter A. Crooks, and Bruce N. Cohen, Brit. J. Pharmacol. , 1999, 128, 1448-1455.
  • " Nornicotine Evokes [3H] Overflow from Rat Nucleus Accumbens Slices Preloaded with [3H]Dopamine. " Thomas A. Green, Michael T. Bardo, Peter A. Crooks, Aaron J. Haubner, and Linda P. Dwoskin, National Institute on Drug Abuse, Research Monograph, 1999, 180, 195.
  • " Stereochemically Defined Lobeline Analogues: Inhibition of [3H]Dopamine Uptake and [3H] Nicotine Binding in Rat Striatum. " Peter A. Crooks, Marlon D. Jones, M. Dathan Chesnut, A. M. Jaromczyk, and Linda P. Dwoskin, National Institute on Drug Abuse, Research Monograph, 1999, 180, 234.
  • " Residence Times and Half-Lives of Nicotine Metabolites in Rat Brain after Acute Peripheral Administration of [2’-14C]Nicotine " . By Omar Ghosheh, Linda P. Dwoskin, Wen-kui Li, and Peter A. Crooks, Drug Metab. Disposit. , 1999, 27, 1448-1455.
  • " Nornicotine is Self-Administered Intravenously by Rats " . By Michael T. Bardo, Thomas A Green, Peter A. Crooks, and Linda P. Dwoskin, Psychopharmacology,1999, 146, 290-296.
  • " Synthesis and Structure-Activity Studies of Some Antitumour Congeners of L-Canaline " . By Supinan R. Na Phuket, Latchezar S. Trifonov, Chongxi Yu, David R. Worthen, Peter Crooks, Gerald A. Rosenthal, and James W. Freeman, Drug Development Research, 1999, 47(4), 170-177.
  • " Use of High-Performance-Liquid Chromatographic and Mass Spectrometric Techniques for the Determination of Nicotine and Its Metabolites " . By Peter A. Crooks and Gary D. Byrd, invited chapter in Analytical Determination of Nicotine and Related Compounds and Their Metabolites &rdquo , Edits. John W. Gorrod and Peyton Jacob III, Elsevier, Oxford, pp 225-264, 1999.
  • " Chemical Properties of Nicotine and Other Tobacco Related Compounds " . By Peter Crooks, invited chapter in Analytical Determination of Nicotine and Related Compounds and Their Metabolites &rdquo , Edits. John W. Gorrod and Peyton Jacob III, Elsevier, Oxford, pp 69-147, 1999.
  • " High Performance Liquid Chromatographic Analysis of the Pharmacologically Active Quinones and Related compounds in the Oil of the Black Seed (Nigella Sativa L.). By Omar A. Ghosheh, Abdulghani A. Houdi, and Peter A. Crooks, J. Pharm. Biomed. Anal. , 1999, 19, 757-762.
  • " A Novel Enantioselective synthesis of (S)-(-)- and (R)-(+)-Nornicotine via Alkylation of a Chiral 2-Hydroxy-3-pinanone Ketimine Template. " By Jason H. Swango, Balwinder S. Bhatti, Muhammad M. Qureshi, and Peter A. Crooks, Chirality, 11, 316-318, 1999.
  • " Development of a Novel Class of Subtype-Selective Nicotinic Receptor Antagonists: Pyridine N-Substituted Nicotine Analogues " . By Linda P. Dwoskin, Lincoln H. Wilkins, James R. Pauly, and Peter A. Crooks, Ann. New York Acad. Sci. , 1999, 868, 617-619.
  • " Acute and Chronic Effects of Nornicotine on Locomotor Activity in Rats: Cross-Reactivity to Nicotine. " By Linda P. Dwoskin, Peter A. Crooks, Melinda B. Marion, LiHong Teng, and Michael T. Bardo, Psychopharmacology, 1999, 145, 442-451.
  • " S-(-)-Cotinine, the Major Brain Metabolite of Nicotine, Stimulates Nicotinic Receptors to Evoke [3H]Dopamine Release from Rat Striatal Slices in a Calcium-Dependent Manner " . By Linda P. Dwoskin, LiHong Teng, Susan T. Buxton, and Peter A. Crooks, J. Pharmacol. Exp. Therap., 1999, 288, 905-911.
  • " Increased Concentrations of Plasma Cotinine in Schizophrenic Smokers Compared to Normal smokers. " Peter A. Crooks, Omar Ghosheh, Linda P. Dwoskin, Thea Rogers, and Jose de Leon, National Institute on Drug Abuse, Research Monograph, 1998, 179, 192.
  • " Interactions of Lobeline and Nicotine with Amphetamine: In Vitro DA Release and Drug Discrimination in Rats. " Linda P. Dwoskin, Jane B. Acri, Peter A. Crooks, LiHong Teng and Jeffrey M. Witkin, National Institute on Drug Abuse, Research Monograph, 1998, 179, 68.
  • " Synthesis of (E)-[Methyl-d3]-4-(pyridinyl)-3-buten-1-amine; a Deuterated Analogue of the Tobacco Alkaloid and Nicotine Metabolite: Metanicotine. " By Peter A.Crooks, Alain Ravard and Gary D. Byrd, J. Labelled Comp. Radiopharm. , 1998, LXI, 1165-1171.
  • " L-Canavanine Modulates Cell Growth, MDR Substrate Accumulation and Chemosensitivity in Human Uterine Sarcoma Cells " . By David R. Worthen, Lynn Chien, Clifford P. Tsuboi, Xi Y. Mu, and Peter A. Crooks, Cancer Letters, 1998, 134, 1-11.
  • " Measurement of Adenosine Concentration in Aqueous and Vitreous " . By Michelle Howard, Harsha A. Sen, Seema Capoor, Rob Herfel, Peter A. Crooks, and Myron K. Jacobson. Inv. Opthalmol. Vis. Sci., 1998, 39(10), 1942-1946.
  • " A Novel Technique for Visualizing the Intracellular Localization and Distribution of Transported Polyamines in Cultured Pulmonary Artery Smooth Muscle Cells " . By Shewan M. Aziz, Mustafa Yatin, David W. Lipke, David R. Worthen, and Peter A. Crooks, J. Pharm. Biomed. Anal. , 1998, 17, 307-320 (1999 Outstanding Manuscript Award in Analysis and Pharmaceutical Quality, American Association of Pharmaceutical Scientists).
  • " Lobeline Displaces [3H]Dihydrotetrabenazine Binding and Releases [3H]Dopamine from Rat Striatal Synaptic Vesicles: Comparison with d-Amphetamine " . By LiHong Teng, Peter A. Crooks and Linda P. Dwoskin, J. NeuroChem., 1998, 71, 258-265.
  • " The Heterocyclic Substituted Pyridine Derivative (?)-2-Azabibicyclo (2.2.1)hept-5-ene (RJR 2429); A Selective Ligand at Nicotinic Acetylcholine Receptors " . By Merouane Bencherif, Jeffrey D. Schmitt, Balwinder S. Bhatti, Peter A. Crooks, William S. Caldwell, M.E. Lovette, K. Fowler, L. Reeves, and Patrick M. Lippiello, J. Pharmacol. Exp. Ther. , 1998, 284, 886-894.
  • " The In Vitro Anti-tumor Activity of Some Crude and Purified Components of Black Seed, Nigella sativa L " . By David R. Worthen, Omar A. Ghosheh, and Peter A. Crooks, Anticancer Research, 1998, 18, 1527-1532.
  • " A Unique Interaction Between Polyamine and MDR (P-Glycoprotein) Transporters in Cultured Chinese Hamster Ovary Cells Transfected with Mouse mdr-1 Gene " . By Shewan M. Aziz, David R. Worthen, Ken Ain, and Peter A. Crooks, Biochem. Pharmacol., 1998, 56, 181 187.
  • " (-)-Nornicotine Partially Substitutes for (+)-Amphetamine in a Drug Discrimination Paradigm in Rats. " By Michael T. Bardo, R. A. Bevins, Jennifer E. Klebaur, Peter A. Crooks, and Linda P. Dwoskin, Pharmacol. Biochem. Behav. , 1997,58(4),1083-1087.
  • " Synthesis and Structure-Activity Studies of Some Antitumour Congeners of L-Canavanine " . By Supinan R. NaPhuket, Latchezar S. Trifanov, Peter A. Crooks, Gerald A. Rosenthal, James W. Freeman, and William E. Strodel, Drug Development Research, 1997, 40, 325-332.
  • " Lobeline and Nicotine Evoke [3H]-Overflow from Rat Striatal Slices Preloaded with [3H]Dopamine: Differential Inhibition of Synaptosomal and Vesicular [3 H]Dopamine Uptake " . By Li Hong Teng, Peter A. Crooks, Patricia K. Sonsalla, and Linda P. Dwoskin, J. Pharmacol. Exp. Ther. , 1997,80, 1432-1444.
  • " Metabolites of Nicotine In Rat Brain After Peripheral Nicotine Administration: Cotinine, Nornicotine and Norcotinine " . By Peter A. Crooks, Min Li, Linda P. Dwoskin, Drug. Metab. Disposit. ,1997, 25(1), 47-54.
  • " Nicotinic-Receptor Mediation of S(-)Nornicotine-Evoked [3H]-Overflow from Rat Striatal Slices Preloaded with [3H] Dopamine " . By Li Hong Teng, Susan T. Buxton, Peter A. Crooks and Linda P. Dwoskin, J. Pharmacol. Exp. Ther. , 1997, 283, 778-787.
  • " Cotinine Pharmacology: Brain Uptake and Metabolism , Effects on Dopamine Release and Lack of Behavioral Sensitization after Chronic Administration to Rats " . By Peter A. Crooks, LiHong Teng, Min Li, Michael T. Bardo, Lincoln H. Wilkins, and Linda P. Dwoskin, National Institute on Drug Abuse, Research Monograph, 1997, Series 174, 203.
  • " Further Characterization of a Novel Class of Nicotinic Receptor Antagonists " . By Linda P. Dwoskin, M. Imad Damaj, David D. Allen, Lincoln H. Wilkins, and Peter A. Crooks, National Institute on Drug Abuse, Research Monograph, 1997, Series 174, 65.
  • " CNS Nicotine Metabolites Contribute to the Neuropharmacological Effects of Nicotine and Tobacco Smoking " . By Peter A. Crooks and Linda P. Dwoskin, Biochem. Pharmacol., 1997, 54, 743-753.
  • " Intravitreal Sustained Release Corticosteroid-5-Fluorouracil Conjugate in the Treatment of Experimental Proliferative Vitreoretinopathy. " By Adam S. Berger, Chang-Kuo Cheng, P. Andrew Pearson, Paul Ashton, Peter A. Crooks, Tadeusz Cynkowski, Grazina Cynkowska, and Glenn J. Jaffe, Invest. Ophthalmol. Vis. Sci. , 1996, 37 (11), 2318-2325.
  • " Potential of a Novel Polyamine Transport Inhibitor in Cancer Chemotherapy " . By Shewan M. Aziz, Mark N. Gillespie, Peter A. Crooks, Sharmen Tofiq, Clifford P. Tsuboi, Jack W. Olson, and Michael P. Gosland, J. Pharmacol. Exp. Therap., 1996, 278, 185 - 192.
  • " Regioselective Alkylation of N-(Diphenylmethylidene)-3-(aminomethyl)-pyridine: A Simple Route to Minor Tobacco Alkaloids and Related Compounds. " By Niranjan M. Deo and Peter A. Crooks, Tetrahedron Letters, 1996, 37(8), 1137-1140.
  • " Neurochemical Characterization of a New Class of Novel Nicotinic Receptor Antagonist " . By Peter A. Crooks, Lincoln H. Wilkins, Li-Hong Teng, Alain Ravard, and Linda P. Dwoskin, National Institute on Drug Abuse, Research Monograph, 1996, Series 162, 286.
  • " Behavioral Sensitization to Nornicotine: Lack of Correlation with [3H] Nicotine Binding in Rat Whole Brain " . By Linda P. Dwoskin, Lincoln H. Wilkins, Peter A. Crooks, M.C. Bradley, and Michael T. Bardo, National Institute on Drug Abuse, Research Monograph, 1996, Series 162, 311.
  • " Structure-Activity Studies of L-Canaline-Mediated Inhibition of Porcine Glutamic-Pyruvic Aminotransferase " . By David R. Worthen, Darian K. Ratliff, Gerald A. Rosenthal, L.Trifonov, and Peter A. Crooks, Chem. Res. Toxicol. , 1996, 9, 1293-1297.
  • " Chiral Purity Determination of Tobacco Alkaloids and Nicotine-Like Compounds by 1H-NMR Spectroscopy in the Presence of 1, 1'-Binaphthyl-2, 2'-diylphosphoric Acid " . By Alain Ravard and Peter A. Crooks, Chirality, 1996, 8 (4), 295-299.
  • " A Dihydromorphine-6-O-sulfate " . By Carolyn Pratt Brock, Santosh Kottayil, D. Allan Butterfield, and Peter A. Crooks, Acta Crystallogr. , 1996, C52, 122-125.
  • " 3-O-Acetylmorphine-6-O-Sulfate: A Potent, Centrally Acting Morphine Derivative " . By Abdulghani A. Houdi, Santosh Kottayil, Peter A. Crooks and D. Alan Butterfield, Pharmacol. Biochem. Behavior, 1996, 53, 665-671.
  • " Reversal of Doxorubicin, Etoposide, Vinblastine, and Taxol Resistance in Multidrug Resistant Human Sarcoma Cells by a Polymer of Spermine " . By Michael P. Gosland, Mark N. Gillespie, Clifford P. Tsuboi, Sharmen Tofiq, Jack W. Olson, Peter A. Crooks and Shewan M. Aziz, Cancer Chemother. Pharmacol., 1996, 37, 593-600.
  • " Large Scale Production and Chemical Characterization of the Protective, Higher Plant Allelochemicals: L-Canavanine and L-Canaline " . By Michael Bass, Peter A. Crooks, H. Levi, Supinan NaPhuket, and Gerald A. Rosenthal. Biochem. System Ecol. , 1995, 25, 717-721.
  • " Reactions of N-Benzoyl Amino Acids with Oxalyl Chloride: A Facile Route to 4-Substituted 2 Phenyloxazole-5-carboxylates " . By Peter A. Crooks, Grazyna Cynkowska, Paul Ashton, and Tadeusz Cynkowski, J. Chem. Soc., Chem. Comm., 1995, (22), 2335-2337.
  • " Determination of Nicotine Metabolites in Rat Brain After Peripheral Radiolabeled Nicotine Administration: Detection of Nornicotine " . By Peter A. Crooks, Min Li, and Linda P. Dwoskin, Drug. Metab. Disposit. , 1995, 23(10), 1175-1177.
  • " Insecticidal Properties of Some L-Canavanine Derivatives " . By Gerald A. Rosenthal, D. L. Dahlman, Peter A. Crooks, Supinan NaPhuket and Latch S. Trifonov. J. Agr. Food Chem., 1995, 43, 2728-2734.
  • " Sustained Release of Synergistic Agents " . By Hong Guo, Tadeusz Cynkowski, Grazyna Cynkowska, Peter A. Crooks, and Paul Ashton, Proc. Int. Symp. Controlled Release Bioact. Mater. , 1995, 22nd, 326-327.
  • " Synthesis of 2-Cyanomethyl-l-methylpiperidine " . By Niranjan M. Deo and Peter A. Crooks, Synth. Commun. , 1995, 25 (5), 691-701.
  • " Design of Novel Prodrugs for the Enhancement of the Transdermal Penetration of Indomethacin " . By Janan A. Jona, Lewis W. Dittert, Peter A. Crooks and Anwar A. Hussain, Int. J. Pharm. , 1995, 123, 127-136.
  • " A Novel Polymeric Spermine Conjugate Inhibits Polyamine Transport in Pulmonary Artery Smooth Muscle Cells " . By Shewan M. Aziz, Michael P.Gosland, Peter A. Crooks, Jack W. Olson and Mark N. Gillespie, J. Pharmacol. Exp. Therap.,1995, 274, 181-186.
  • " Minor Alkaloids of Tobacco Release [3H]-Dopamine from Superfused Rat Striatal Slices " . By Linda P. Dwoskin, LiHong Teng, Susan T. Buxton, Alain Ravard, Niranjan Deo, YingShi Guo and Peter A. Crooks, Eur. J. Pharmacol. , 1995, 276, 195-199.
  • " Kinetics and Mechanism of Hydrolysis of Amidals: Their Relative Stability Compared to Structurally Related Acetals and Acylals. " By Jianbing Chen, Peter A. Crooks, and Anwar Hussain , Int. J. Pharmac., 1995, 123, 95-101.
  • " Inhibition of Nicotine-Evoked Dopamine Release by Pyridino N-Substituted Nicotine Analogues: A New Class of Nicotinic Antagonist " . By Peter A. Crooks, Alain Ravard, Li Hong Teng, and Linda P. Dwoskin, Drug Development Res. , 1995, 36, 71-82.
  • " Combination Therapy with 5-Fluorouracil and L-Canavanine: In Vitro and In Vivo Studies " . By Diane S. Swaffar, Choo Y. Ang, Pankaj B. Desai, Deborah A. Thomas, Peter A. Crooks, William J. John, and Gerald A. Rosenthal. Anti-Cancer Drugs, 1995, 6, 586-593.
  • " Direct Determination of Cotinine-N-Glucuronide in Urine Using Thermospray Liquid Chromatography/Mass Spectrometry " . By Gary D. Byrd, M.S. Uhrig, William S. Caldwell, J. Donald deBethizy, Peter A. Crooks, Alain Ravard, and Robert M. Riggs, Biological Mass Spectrom. ,1994, 23, 103-107.
  • " Modern Instrumental Methods for Studying Mechanisms of Toxicity " . By William S. Caldwell, J. Donald deBethizy, Peter A. Crooks and Gary D. Byrd, invited chapter in: Principles and Methods in Toxicology, Third Edition, A. Wallace Hayes ed., Chapter 37, New York, Raven Press, pp. 1335 - 1390, 1994.
  • " Lobeline Robustly Increases Tritiated Dopamine Release from Rat Striatal Slices " . By Linda P. Dwoskin, LiHong Teng, Susan T. Buxton and Peter A. Crooks, National Institute on Drug Abuse, Research Monograph, 1994, Series 142, 191.
  • " Synthesis of [Methyl-d3]-Labeled Cis- and Trans-3'-Hydroxycotinine " . By Alain Ravard and Peter A. Crooks, J. Labelled Comp. Radiopharm. , 1994, 34, 1001-1009.
  • " N-Oxidation, N-Methylation and Conjugation Reactions of Nicotine " . By Peter A. Crooks, invited chapter in Biochemistry and Metabolism of Nicotine and Related Alkaloids &rdquo , Edit. John W. Gorrod and John Wahren, Chapman Hall, London, Chapter 5, pp 81-109, 1993.
  • " S(-)-Nornicotine Increases Dopamine Release in a Calcium-Dependent Manner from Superfused Rat Striatal Slices " . By Linda P. Dwoskin, Susan T. Buxton, Ann L. Jewell and Peter A. Crooks, J. Neurochem. , 1993, 60, 2167-2174.
  • " Conformational Studies of the Thymidine Dimers Containing Sulfonate and Sulfonamide Linkages by NMR Spectroscopy " . By C. Glemarec, R.C. Reynolds, P.A. Crooks, J.A. Maddry, M.S. Akhtar, J.A. Montgomery, J.A. Secrist, III, and J. Chattopadhyaya, Tetrahedron, 1993, 49, 2287-2298.
  • " Triazolines 24. Permanganate-Catalyzed Low Temperature Thermolysis of ?2-1,2,3 Triazolines " . By Pankaja K. Kadaba, Gordon Parmley, Peter A. Crooks and Bushra J. Agha, J. Heterocyclic Chem., 1993, 30, 1191-1196.
  • " Detection of a Possible Biomarker for Sidestream Cigarette Smoke Exposure " . By Abdulghani A. Houdi, C. Steven Godin and Peter A. Crooks, Pharm. Sci. Commun. , 1993, 4, 15-20.
  • " Chloramine-T in Radiolabelling Techniques " . I. Kinetics and Mechanism of the Reaction Between Chloramine-T and Amino Acids. By Anwar A. Hussain, Riad Awad, Peter A. Crooks and Lewis W. Dittert, Analyt. Biochem. , 1993, 214, 495-499.
  • " Gas Chromatographic Determination of Residual Levels of t-Butanol from Lyophilized Liposomal Formulations " . By Prasad V. Gogineni, Peter A.Crooks and Ram B. Murty, J. Chromatogr. Biomed. Appl. , 1993, 620, 83-88.
  • " Nornicotine-Induced Dopamine Release from Rat Striatal Slices is Concentration-Dependent, Calcium-Dependent and Stereoselective " . By Linda P. Dwoskin, Susan T. Buxton, LiHong Teng and Peter A. Crooks, National Institute on Drug Abuse, Research Monograph, 1993, Series 141, 249.
  • " Drug Targeting to the Lung: Chemical and Biochemical Considerations " . By Peter A. Crooks, invited chapter in Pharmaceutical Aerosol Technology &rdquo , Edit. Anthony Hickey, Marcel Dekker, Inc., NY, Chapter 4, pp 83-127, 1992.
  • " Kinetics and Mechanisms of Chlorine Exchange Between Chloramine-T and Secondary Amines " . By Hana Dannan, Peter A. Crooks, Lewis W. Dittert, and Anwar A. Hussain, J. Pharm. Sci. , 1992, 81, 652-656.
  • " Structure-Activity Considerations in the Kinetics and Mechanism of Chlorine Exchange Between Chloramine-T and Secondary Amines " . By Hana Dannan, Anwar A. Hussain, Peter A. Crooks, and Lewis W. Dittert, J. Pharm. Sci. , 1992, 81, 657-660.
  • " Inhibition of [3H]-Dopamine Uptake into Rat Striatal Slices by Quaternary N-Methylated Nicotine Metabolites " . By Linda P. Dwoskin, L.L. Leibee, Ann L. Jewell, Zhou-Xia Fang and Peter A. Crooks, Life Sciences,1992, 50, PL-233 - PL-237.
  • " Nucleoside Sultones: Synthons for the Preparation of Novel Nucleotide Analogs. I. Synthesis and Ring Opening Reactions " . By Peter A. Crooks, Robert C. Reynolds, Joseph A. Maddry, Anita Rathore, John A. Montgomery, and John A. Secrist, III, J. Org. Chem., 1992, 57, 2830 2835.
  • " Characterization of the Glucuronide Conjugate of Cotinine: A Previously Unidentified Major Metabolite of Nicotine in Smoker's Urine " . By William S. Caldwell, Jackie M. Greene, Gary D. Byrd, K.M. Chang, M.S. Uhrig, J. Donald deBethizy, Balwinder S. Bhatti, Robert M. Riggs and Peter A. Crooks, Chem. Toxicol. Res. , 1992, 5, 280-285.
  • " Formation of a Novel 2,3-Dihydro-1,4-oxazine Nucleoside via Condensation of Adenosine Dialdehyde with Benzylamine " . By Robert M. Riggs and Peter A. Crooks, Chemistry and Industry (London) , 1992, 220-221.
  • " Synthesis of a Thymidine Dimer Containing an Internucleoside Sulfonamide Linkage " . By Robert C. Reynolds, Peter A. Crooks, Joseph A. Maddry, M. Shamim Akhtar, John A. Montgomery, and John A. Secrist, III. J. Org. Chem., 1992, 57, 2983-2985.
  • " 4-Trimethylammonium Antipyrine, A Quaternary Ammonium Non-Radionuclide Marker for Blood-Brain Barrier Integrity During In Vivo Microdialysis " . By David D. Allen, Peter A. Crooks and Robert A. Yokel, J. Pharmacol. Toxicol. Methods, 1992, 28, 129-135.
  • " Enantiomeric Purity of Nicotine in Tobacco Smoke " . By Peter A. Crooks, C. Steven Godin and William F. Pool, Med. Sci. Res. , 1992, 20, 879-880.
  • " Oxidative Metabolism of Nicotine Enantiomers in Cultured Guinea Pig Hepatocytes " . By Peter A. Crooks, Amanda J. Sherratt, and C. Steven Godin, Med. Sci. Res, , 1992, 20, 909-911.
  • " Synthesis of N-Glucuronic Acid Conjugates of Cotinine, cis-3?-Hydroxycotinine, and trans-3' Hydroxycotinine " . By Peter A. Crooks, Balwinder S. Bhatti, Alain Ravard, Robert M. Riggs and William S. Caldwell, Med. Sci. Res. , 1992, 20, 881-883.
  • " Lung Peptidases and Their Activities " . By Peter A. Crooks, Respiratory Drug Delivery II, 1991, Volume 1, pp 50-103.
  • " Progress Toward the Synthesis of Nonionic Oligonucleotide Analogues with Sulfonate and Sulfonamide Internucleoside Linkages " . By John A. Secrist III, Peter A. Crooks, Joseph A. Maddry, Robert C. Reynolds, Anita S. Rathore, M. Shamim Ahktar, and John A. Montgomery. Proceedings of First International Symposium on Synthetic Oligonucleotides, Moscow, Russia, June 24-28, 1991, Nucleic Acids Research, Symposium Series, 1991, 24, 5-8.
  • " The Synthesis and Antiviral Activity of 5'-Amino-3'-azido-3',5'-dideoxythymidine " . By Robert C. Reynolds, Peter A. Crooks, Joseph A. Maddry, John A. Montgomery and John A .Secrist III, J. Biopharmaceutical Sci. , 1991, 2(3), 195-203.
  • " Drug Application to the Respiratory Tract: Metabolic and Pharmacokinetic Considerations. " By Peter A. Crooks and Lyaquatali A. Damani, invited chapter in Respiratory Drug Delivery &rdquo , Edit. Peter R. Byron, CRC Press, Inc. Cleveland, OH, USA, Chapter 3, 1990, pp 61-90.
  • " Rearrangement of O-Acetylsalicylamides via Intramolecular O to N Transacylation: Rate Enhancement by an Adjacent Carboxylic Acid Group " . By Fatima A. Tawfig, Lewis W. Dittert, Anwar A. Hussain and Peter A. Crooks, J. Pharm. Sci. , 1990, 79, 651.
  • " Triazolines XVII. Metabolism and Disposition of 14C-ADD 17014[1-(4-chlorophenyl)-5-(4-pyridyl) ?2-1,2,3-triazoline], a Novel Triazoline Anticonvulsant: Preliminary Studies in the Rat " . By Terence T. Tita, Pankaja K. Kadaba, and Peter A. Crooks, J. Biopharm. Science, 1990, 1, 171 180.
  • " Kinetics and Mechanism of Decomposition of N-Chloro-?-amino Acids " . By Riad Awad, Anwar Hussain and Peter A. Crooks, J. Chem. Soc. Perk. Trans. II, 1990, 1233-1238.
  • " Kinetics and Mechanism of Decomposition of N-Chloro-?-amino Acids. II. Conformationally Restricted Models " . By Riad Awad, Anwar A. Hussain and Peter A. Crooks, J. Pharm. Sci. , 1990, 79, 1121-1122.
  • " Kinetics of Decomposition of O-Acyl Derivatives of Salicylamide and Related Compounds " . By Fatima A. Tawfig, Lewis W. Dittert, Anwar A. Hussain, and Peter A. Crooks, International J. Pharmaceutics. , 1990, 64, 43-55.
  • " 5'-Thioadenosine Derivatives as Potent and Selective Inhibitors of Histamine N Methyltransferase " . By Peter A. Crooks, Samira F. Hassan, Eric Benghiat, Susan K. Hemrick Luecke and Ray W. Fuller, Drug Metab. Drug Interact. , 1989, 7, 111-141.
  • " Metabolism of the Sulphonamido Group. " By Peter A. Crooks, invited chapter in Sulphur Drugs and Related Organic Chemicals - Chemistry, Biochemistry and Toxicology &rdquo , Chapter 7, Edit. Lyaquatali A. Damani, Vol. 1, Part B, Ellis Horwood Limited, Chichester, U.K., 1989, pp 181-194.
  • " Sulphonium Salts. " By Peter A. Crooks, invited chapter in Sulphur Drugs an Related Organic Chemicals-Chemistry, Biochemistry and Toxicology &rdquo , Edit. Lyaquatali A. Damani, Vol. 1, Part B, Ellis Horwood Limited, Chichester, U.K., Chapter 6, 1989, pp 155-180.
  • " Interaction of Sulphur Xenobiotics with S-Adenosyl-L-methionine-dependent Methyltransferase Reactions. " By Peter A. Crooks, invited chapter in Sulphur Drugs and Related Organic Chemicals - Chemistry, Biochemistry and Toxicology &rdquo , Edit. Lyaquatali A. Damani, Vol. 2, Part B, Ellis Horwood Limited, Chichester, U.K., Chapter 2, 1989, pp 47-85.
  • " Nasal Absorption and Metabolism of Progesterone and 17?-Estradiol in the Rat. " By Rima N. Bawarshi-Nassar, Anwar A. Hussain and Peter A. Crooks, Drug Metabol. Disposit. , 1989, 17, 248-254.
  • " N-Methylation as a Toxication Route for Xenobiotics. II. In Vivo Formation of N,N'-Dimethyl 4,4'-bipyridinium Ion (Paraquat) from 4,4'-bipyridyl in the Guinea Pig " . By C. Steven Godin and Peter A. Crooks, Drug Metabol. Disposit. , 1989, 17, 180-185.
  • " Nasal Absorption of 17-Ethinyl Estradiol in the Rat " . By Rima N. Bawarshi-Nassar, Anwar A. Hussain and Peter A. Crooks, J. Pharm. Pharmacol. , 1989, 41, 214-216.
  • " Differential Effect of Nicotine on Plasma Norepinephrine Levels in Normal Humans and in Patients with Congestive Heart Failure " . By Steven R. Goldsmith, Donna Dodge-Brown, Adriana Katz and Peter A. Crooks, Amer. J. Cardiology, 1989, 63, 122-123.
  • " Synthesis of 5-Benzoyl-5-phenyl- and 5-Phenylhydroxymethyl-5-phenylhydantoins as Potential Anticonvulsants " . By Peter A. Crooks, Trevor Deeks, and Francesco DeSimone, J. Heterocyclic Chem., 1989, 26, 1113-1117.
  • " Kinetics and Mechanism of the Reactions of Hypochlorous Acid and Monochloramine with N Acetylcysteine " . By Prakash Kulkarni, Anwar A. Hussain, and Peter A. Crooks, Proc. Fourth Conference on Prog. Chem. Disinfection, 1988, 399-407.
  • " High Performance Liquid Chromatography of Radiolabeled Nicotine Enantiomers and Their Metabolism in the Guinea Pig to N-Methylated Products " . By Peter A. Crooks and Kenneth C. Cundy, invited chapter in &rdquo Flow Through Radioactive Detectors in HPLC &rdquo . Progress in HPLC, Vol. 4, Edit. H. Parvez, M. Kessler and S. Parvez, V.N.U. International Science Press, Utrecht, Holland, 1988, pp 129-147.
  • " N-Methylation of Nicotine Enantiomers by Human Liver Cytosol " . By Peter A. Crooks and C. Steven Godin, J. Pharm. Pharmacol. , 1988, 40, 153-154.
  • " High Performance Liquid Chromatography with Electrochemical Detection for the Determination of Nicotine in Plasma " . By Chen-Yie Chien, John N. Diana and Peter A. Crooks, J. Pharm. Sci. , 1988, 77, 277-279.
  • " Determination of Plasma Nicotine by High Performance Liquid Chromatography with Electrochemical Detection " . By Chen-Yie Chien, John N. Diana and Peter A. Crooks, LC-GC, Mag. Liq. Gas Chromatogr. , 1988, 6, 53-55.
  • " Formation of Quaternary Amines by N-Methylation of Azaheterocycles with Homogenous Amine N-Methyltransferases. " By Peter A. Crooks, C. Steven Godin, Lyaquatali A. Damani, Sherry S. Ansher and William B. Jakoby, Biochem. Pharmacol. , 1988, 37, 1673-1677.
  • " N-Methyl-N'-oxonicotinium Ion: Synthesis and Stereochemistry. " By Peter A. Crooks, William F. Pool, Lyaquatali A. Damani and Stephen A. Winkle, Chemistry and Industry (London) , 1988, 95-96.
  • " Inhibition of Histamine N-Methyltransferase Activity in Guinea Pig Pulmonary Alveolar Macrophages by Nicotine " . By Chandrachuranan Gairola, C. Steven Godin, Abdulghani Al Houdi, and Peter A. Crooks, J. Pharm. Pharmacol. , 1988, 40, 724-726.
  • " Stereoselectivity in the N'-Oxidation of Nicotine Isomers by Flavin-Containing Monooxygenase " . By Lyaquatali A. Damani, William F. Pool, Peter A. Crooks, R. Keith Kaderlik, and Daniel M. Ziegler, Mol. Pharmacol., 1988, 33, 702-705.
  • " Equilibrium Binding of Spermine and Histamine to Salmon Sperm DNA and Poly(dGdC) " . By Stephen A. Winkle and Peter A. Crooks, J. Pharm. Pharmacol., 1988, 40, 809-811.
  • " Response of Plasma Arginine Vasopressin to Nicotine in Normal Man " . By Steven R. Goldsmith, Adriana Katz and Peter A. Crooks, Clin. Pharmacol. Ther. , 1988, 44, 478-481.
  • " Effect of Continuous Nicotine Administration on Urinary Histamine and N?? Methylhistamine Levels in the Guinea Pig " . By Abdulghani A. Houdi, C. Steven Godin and Peter A. Crooks, Toxicol. Letters, 1988, 44, 161-166.
  • " Biotransformation of Primary Nicotine Metabolites, III. Metabolism of R-(+)-[3H-N'-CH3;14C-N CH3]-N-methylnicotinium Acetate - The Use of Double Isotope Studies to Determine the In Vivo Stability of the N-methyl Groups of N-methylnicotinium Ion " . By William F. Pool and Peter A. Crooks, J. Pharm. Pharmacol., 1988, 40, 758-762.
  • " Species Variation and Stereoselectivity in the Metabolism of Nicotine Enantiomers " . By Chukwuemeka G. Nwosu and Peter A. Crooks, Xenobiotica, 1988, 18, 1361-1372.
  • " Enantioselective Metabolism During Continuous Administration of S-(-)- and R-(+)-Nicotine Isomers in Guinea Pigs " . By Chukwuemeka G. Nwosu, C. Steven Godin, Abdulghani A. Houdi, Lyaquatali A. Damani and Peter A. Crooks, J. Pharm. Pharmacol. , 1988, 40, 862-869.
  • " Biotransformation of Primary Nicotine Metabolites II. Metabolism of 3H-S-(-)-Cotinine in the Guinea Pig: Determination of In Vivo Urinary Metabolites by High-Performance Liquid Radiochromatography " . By Kenneth C. Cundy and Peter A. Crooks, Xenobiotica.,, 1987, 17, 785-792.
  • " Perturbation of S-Adenosylhomocysteine and S-Adenosylmethionine Levels, and Inhibition of Histamine Metabolism in the Guinea Pig, By Nicotine " , Tobacco Smoking and Health, International Symposium, Lexington, Kentucky, December, 1985; in Tobacco Smoking and Nicotine: A Neurobiological Approach, edited by William R. Martin, Glen R. Van Loon, Edgar T. Iwamoto, and Layten Davis, p. 500, Plenum Press, New York and London, 1987.
  • " In Vitro and In Vivo Biomethylation of Nicotine Enantiomers " , Tobacco Smoking and Health, International Symposium, Lexington, Kentucky, December, 1985; in Tobacco Smoking and Nicotine: A Neurobiological Approach, edited by William R. Martin, Glen R. Van Loon, Edgar T. Iwamoto, and Layten Davis, p. 499, Plenum Press, New York and London, 1987.
  • " Stereospecific N-Methylation of Nicotine by Intact Guinea Pig Pulmonary Alveolar Macrophages " , Tobacco Smoking and Health, International Symposium, Lexington, Kentucky, December, 1985; in Tobacco Smoking and Nicotine: A Neurobiological Approach, edited by William R. Martin, Glen R. Van Loon, Edgar T. Iwamoto, and Layten Davis, p. 497, Plenum Press, New York and London, 1987.
  • " A Simple and Sensitive Determination of Histamine and N?-Methylhistamine in Biological Fluids by High-Performance Liquid Chromatography with Electrochemical Detection " . Abdulghani Al Houdi, Peter A. Crooks, Glen R. Van Loon, and Cathryn A.W. Schubert, J. Pharm. Sci., 1987, 76, 398-401.
  • " Inhibition of Vaccinia RNA Guanine 7-methyltransferase by Compounds Designed as Multisubstrate Adducts " . By Eric Benghiat, Peter A. Crooks, Raymond Goodwin and Fritz Rottman, J. Pharm. Sci. , 1986, 75, 142-145.
  • " N-Methylation and Quaternization of Pyridine In Vitro by Rabbit Lung, Liver and Kidney N Methyltransferases: An S-Adenosyl-L-Methionine-Dependent Reaction " . By Lyaquatali A. Damani, Mamhoud S. Shaker, Peter A. Crooks, C. Steven Godin, and Chukwuemka G. Nwosu, Xenobiotica, 1986, 16, 645-650.
  • " Reevaluation of the Products of Tryptamine Catalyzed by Rabbit Liver N-methyltransferases " . By Peter A. Crooks, C. Steven Godin, Chukwuemeka G. Nwosu, Sherry S. Ansher and William Jakoby, Biochem. Pharmacol. , 1986, 35, 1600-1603.
  • " The Ability of Amine N-Methyltransferases from Rabbit Liver to N-Methylate Azaheterocycles " . By Lyaquatali A. Damani, Mahmoud S. Shaker, C. Steven Godin, Peter A. Crooks, Sherry S. Ansher and William Jakoby, J. Pharm. Pharmacol. , 1986, 38, 547-550.
  • " In Vivo Depletion of S-Adenosyl-L-homocysteine and S-Adenosyl-L-methionine in Guinea Pig Lung After Chronic S-(-)-Nicotine Administration " . By C. Steven Godin and Peter A. Crooks, Toxicol. Letters, 1986, 31, 23-29.
  • " A Serendipitous Synthesis of 2-Amino-cis-bicyclo[4.3.0]Nonane " . By Peter A. Crooks, Chemistry and Industry (London) , 1986, 462-463.
  • " Isolation and Characterization of N-Methyl-N'-oxonicotinium ion, A New Urinary Metabolite of R-(+)-Nicotine in the Guinea Pig " . By William F. Pool, Abdulghani A. Houdi, Lyaquatali A. Damani, W. John Layton, and Peter A. Crooks, Drug Metab. Disposit. , 1986, 14, 574-579.
  • " Synthesis of 2-Amino-1,2,3,4-tetrahydro-6,7-dihydroxy -1,4-methanonaphthalen-2-carboxylic Acid- A Conformationally Rigid Analogue of 3,4-Dihydroxyphenylalanine (DOPA) " . By Everett J. Horn, W. John Layton, Stanford L. Smith and Peter A. Crooks, Chemistry and Industry (London) , 1986, 615-616.
  • " In Vitro Inhibition of Histamine Metabolism in Guinea Pig Lung by S-(-)-Nicotine " . By C. Steven Godin and Peter A. Crooks, J. Pharm. Sci. , 1986, 75 949-951.
  • " Synthesis and Antinociceptive Properties of a Series of Exo- and Endo-6-hydroxy-2 aminobenzonorbornenes " . By Peter A. Crooks, Peter Burn, Robert D.E. Sewell, and Neil Upton, J. Pharm. Sci. , 1986, 75, 1010-1013.
  • " S-Acylation of Cysteine by O-Acetylsalicylic Anhydride - A Possible Mechanism for Aspirin Hypersensitivity? " By Hana Dannan, M.N. Khawam, Joseph B. Bogardus, Anwar A. Hussain and Peter A. Crooks, J. Pharm. Sci. , 1986, 75, 1081-1084.
  • " N-methylation of Phenylpyridines and Bispyridyls as a Potential Toxication Route: Tissue Distribution of Azaheterocycle N-Methyltransferase Activity in the Rabbit. " By C. Steven Godin, Peter A. Crooks and Lyaquatali A. Damani, Toxicol. Lett. , 1986, 34, 217-222.
  • " Stereospecific In Vivo N-Methylation of Nicotine in the Guinea Pig " . By Kenneth C. Cundy, Michio Sato and Peter A. Crooks, Drug Metab. Disposit. , 1985, 13, 175-185.
  • " N-Methylnornicotinium Ion, A New In Vivo Metabolite of R-(+)-Nicotine " . By Michio Sato and Peter A. Crooks, Drug Metab. Disposit. , 1985, 13, 348-353.
  • " Synthesis and Pharmacological Evaluation of Aromatic Dihydroxylated Spiro [indan-1,3' pyrrolidine] and Spiro[indan 2,2'-pyrrolidine] Derivatives " . By Richard Sommerville, Howard E. Rosenberg, and Peter A. Crooks, J. Pharm. Sci. , 1985, 74, 553-555.
  • " Pulmonary Metabolism of Exogenous Enkephalins in Isolated Perfused Rat Lungs " . By Mark N. Gillespie, Jerzy W. Krechniak, Peter A. Crooks, Jack W. Olson and Ralph J. Altiere, J. Pharmacol. Exp. Therap., 1985, 232, 675-681.
  • " Remarkable Substrate-Inhibitor Properties of Nicotine Enantiomers Towards a Guinea Pig Lung Aromatic Azaheterocycle N-Methyltransferase " . By Kenneth C. Cundy, Peter A. Crooks and C. Steven Godin, Biochem. Biophys. Res. Commun. , 1985, 128, 312-316.
  • " High-Performance Liquid Chromatographic Analysis of Pulmonary Metabolites of Leu- and Met-Enkephalins in Isolated Perfused Rat Lung " . By Peter A. Crooks, Jerzy W. Krechniak, Mark N. Gillespie and Jack W. Olson, J.Pharm. Sci. , 1985, 74, 1010-1012.
  • " Reaction of 5,6-Benzobicyclo[2.2.1]hepta-2,5-diene with Thallium(III) Nitrate. " By W. John Layton, Carolyn P. Brock, Peter A. Crooks, Stanford L. Smith and Peter Burn, J. Org. Chem., 1985, 50, 5372-5375.
  • " In Vitro Characteristics of Guinea Pig Lung Aromatic Azaheterocycle N-Methyltransferase " . By Kenneth C. Cundy and Peter A. Crooks, Drug Metab. Disposit. , 1985, 13, 658-663.
  • " Biotransformation of Primary Nicotine Metabolites. I: In Vivo Metabolism of R-(+)-[14C-NCH3] N-Methylnicotinium Ion in the Guinea Pig " . By William F. Pool and Peter A. Crooks, Drug Metab. Disposit., 1985, 13, 578-581.
  • " Effect of Nicotine and N'-Nitrosonornicotine on Rat Lung and Trachea Ornithine Decarboxylase Activity " . By Jack W. Olson and Peter A. Crooks, Carcinogenesis, 1985, 6, 1517-1519.
  • " High-Performance Liquid Chromatography with Electrochemical Detection for the Determination of Nicotine and N-Methylnicotinium Ion " . By Shaker Mousa, Abdulghani Al Houdi, Glen R. Van Loon and Peter A. Crooks, J. Chromatogr. , 1985, 347, 405-410.
  • " Stereospecific In Vitro N-Methylation of Nicotine in Guinea Pig Tissues by an S Adenosylmethionine-Dependent N-methyltransferase " By Kenneth C. Cundy, C. Steven Godin and Peter A. Crooks, Biochemical Pharmacol. , 1985, 34, 281-284.
  • " Evidence of Stereospecificity in the In Vivo Methylation of [14C]-(?)- Nicotine in the Guinea Pig " . By Kenneth C. Cundy, C. Steven Godin and Peter A. Crooks, Drug Metab. Disposit. , 1984, 12, 755-759.
  • " Structure-Activity Evidence Against Opiate Receptor Involvement in Leu5-Enkephalin-Induced Pulmonary Vasoconstriction " . By Peter A. Crooks, Bruce D. Bowdy, Carol N. Reinsel, Edgar T. Iwamoto and Mark N. Gillespie, Biochemical Pharmacol. , 1984, 33, 4095-4098.
  • " Leu-Enkephalin Provokes Naloxone-Insensitive Pulmonary Vasoconstriction " . By Mark N. Gillespie, Bruce D. Bowdy, Carol N. Reinsel, Edgar T. Iwamoto and Peter A. Crooks, Life Sciences, 1984, 34, 1177-1183.
  • " Synthesis and Stereochemical Analysis of 2-Amino-1,2,3,4-tetrahydro-1,4 methanonaphthalene-2-carboxylic acid, A Conformationally Rigid Phenylalanine Derivative " . By W. John Layton, Stanford L. Smith, Peter A. Crooks, Trevor Deeks and Roger D. Waigh, J. Chem. Soc., Perkin Trans. I, 1984, 1283-1287.
  • " Reaction of Dimethyloxosulphonium Methylide with Aromatic Methoxylated 1,2,3,4 Tetrahydronaphthalene-1-ones " . By Peter A. Crooks and Richard Sommerville, Chemistry and Industry (London) , 1984, 351-352.
  • " Inhibition of Bacterial DNA Cytosine-5-methyltransferase by S-Adenosyl-L-homocysteine and Some Related Compounds " . By Peter A. Crooks, Malcolm J. Tribe and Richard J. Pinney, J. Pharm. Pharmacol. , 1984, 36, 85-89.
  • " High-Performance Liquid Chromatographic Method for the Determination of N- Methylated Metabolites of Nicotine " . By Kenneth C. Cundy and Peter A. Crooks, J. Chromatogr. Biomed. Appl. , 1984, 306, 291-301.
  • " Leucine Enkephalin Analogues Containing A Conformationally Restrained N-Terminal Amino Acid Residue " . By Trevor Deeks, Peter A. Crooks and Roger D. Waigh, J. Pharm. Sci. , 1984, 73, 457-460.
  • " Differential Metabolism of [2'-14C]-Nicotine and [N-14CH3]-Nicotine in the Guinea Pig " . By Kenneth C. Cundy and Peter A. Crooks, J. Pharm. Pharmacol. , 1983, 35, 75P.
  • " Unexpected Phenomenon in the High-Performance Liquid Chromatographic Analysis of Racemic 14C-Labeled Nicotine: Separation of Enantiomers in a Totally Achiral System " . By Kenneth C. Cundy and Peter A. Crooks, J. Chromatography, 1983, 281, 17-23.
  • " Multisubstrate Adducts as Potential Inhibitors of S-Adenosylmethionine Dependent Methylases: Inhibition of Indole N-Methyltransferase by (5'-Deoxyadenosyl)[3-(3-indolyl)prop-1 yl]methylsulfonium and (5'- Deoxyadenosyl)[4-(3-indolyl)but-1-yl]methylsulfonium Salts " . By Eric Benghiat and Peter A. Crooks, J. Medicin. Chem., 1983, 26, 1470-1477.
  • " Reaction of 2-Acetamido-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one with Dimethyl- amine and Formaldehyde. Formation of Two Isomeric Mannich Bases " By Eric Benghiat and Peter A. Crooks, J. Heterocyclic Chem., 1983, 20, 1023-1025.
  • " Synthesis of Endo- and Exo-2-Amino-6-hydroxybenzonorbornenes - Rigid Analogues of Tyramine " . By Peter A. Crooks and Peter Burn, Chemistry and Industry (London) , 1983, 644 645.
  • " Synthesis and Analgesic Properties of Two Leucine-Enkephalin Analogues Containing a Conformationally Restrained N-Terminal Tyrosine Residue. By Trevor Deeks, Peter A. Crooks and Roger D. Waigh, J. Medicin. Chem., 1983, 26, 762-765.
  • " Synthesis of S-3-Indolemethyl Derivatives of 5'-Deoxy-5'-thioadenosine " . By Eric Benghiat and Peter A. Crooks, J. Heterocyclic Chem., 1983, 20, 423-425.
  • " Synthesis of S-5-Pyrrolo[2,3-b]pyridinemethyl and S-5- and S-6-Pyrrolo[2,3-d]pyrimidinemethyl Derivatives of 5'-Deoxy-5'-thioadenosine " . By Eric Benghiat and Peter A. Crooks, J. Heterocyclic Chem., 1983, 20, 677-680.
  • " ?-2-Adrenoceptor Agonist Properties of Exo- and Endo-isomers of 2-Amino-6, 7 dihydroxybenzonorbornenes Designed as Rigid Catecholamines " . By Peter Hicks, Christopher Waldron, Peter Burn and Peter A. Crooks, J. Pharm. Pharmacol. , 1983, 35, 94-99.
  • " Determination of Benzalkonium Chloride by Chemical Ionization Mass Spectroscopy " . By Nabil N. Daoud, Peter A. Crooks, Richard Speak and Peter Gilbert, J. Pharm. Sci. , 1983, 72, 290-292.
  • " Synthesis of 7-Deazaguanine (2-amino-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one) analogues substituted at C-8 " . By Eric Benghiat and Peter A. Crooks, Chemistry and Industry (London) , 1982, 661-662.
  • " Synthesis of 2,3,3a,8a-Tetrahydroindeno[2,1-b]pyrrole Derivatives " . By Peter A. Crooks, Francesco DeSimone and Eliseo Ramundo, J. Heterocyclic Chem., 1982, 19, 1433-1436.
  • " Preparation of S-(3-Indolemethyl) Derivatives of Mercaptoamino Acids " . By Eric Benghiat and Peter A. Crooks, Synthesis, 1982, 12, 1033-1036.
  • " Oxidative Metabolism of Heterocyclic Ring Systems " . By Lyaquatali A. Damani and Peter A. Crooks, Invited Chapter in Metabolic Basis of Detoxification, Chapter 4, pp 69-89. Edit. William Jakoby, John R. Bend and John Caldwell, Academic Press, Inc., New York, 1982.
  • " The Synthesis and Analgesic Activities of Some Spiro [indan-1, 3'-pyrrolidine] Derivatives Designed as Rigid Analogs of Profadol " . By Peter A. Crooks and Richard Sommerville, J. Pharm. Sci. , 1982, 71, 291-294.
  • " Synthesis and Dopaminergic Properties of Some Exo- and Endo-2-Aminobenzonorbornenes Designed as Rigid Analogues of Dopamine " . By Peter Burn, Peter A. Crooks, Frank Heatley, Brenda Costall, Robert J. Naylor and Virinder Nohria, J. Medicin. Chem., 1982, 25, 363-368.
  • " High-Performance Liquid Chromatographic Analysis of the In Vivo Metabolites of 14C Pyridine " . By Mamhoud S. Shaker, Peter A. Crooks, Lyaquatali A. Damani, J. Chromatography, 1982, 237, 489-495.
  • " Species Differences in the Metabolic C- and N-Oxidation, and N-Methylation of [14C]-Pyridine In Vivo " . By Lyaquatali A. Damani, Peter A. Crooks, Mamhoud S. Shaker, John Caldwell, J. D'Souza and R.L. Smith, Xenobiotica, 1982, 12, 527-534.
  • " Synthesis of N-Oxide Derivatives of Metyrapone and their Detection as In Vitro Metabolites " . By Peter A. Crooks, Lyaquatali A. Damani and David A. Cowan, J. Pharm. Pharmacol. , 1981,33, 309-312.
  • " Metabolism of Metyrapone. 2. Chromatographic and Mass Spectral Properties of the N oxides of Metyrapone and Metyrapol " . By Lyaquatali A. Damani, Peter A. Crooks and David A. Cowan, Biomed. Mass Spectrom. , 1981, 8, 270-277.
  • " Metabolism of Metyrapone. III. Formation of an ?-Pyridone Metabolite by Rat Hepatic Soluble Enzymes " . By Lyaquatali A. Damani, Peter A. Crooks and David A. Cowan, Drug Metab. Disposit. , 1981, 9(3), 270-273.
  • " Baeyer-Villiger Oxidation of Metyrapone during N-Oxide Formation " . By Peter A. Crooks, Lyaquatali A. Damani and David A. Cowan, Chemistry and Industry (London) , 1981, 335-336.
  • " Synthesis of Isomeric 2-Amino-1,3-Dihydroxyindanes from Ninhydrin " . By Peter A. Crooks, Trevor Deeks, Francesco DeSimone and Eliseo Ramundo, Chemistry and Industry (London) , 1981, 392-393.
  • " Inhibition of Bacterial DNA Methylation by S-Tubercidinylhomocysteine. " By Malcolm J. Tribe, Richard J. Pinney anPeter A. Crooks, J. Pharm. Pharmacol. , 1981, 33, 80P.
  • " Identification of Component Alkyl Chains Within Commercial Samples of Benzalkonium Chloride Mixtures by Chemical Ionisation Mass Spectrometry " . By Nabil N. Daoud, Peter A. Crooks and Peter Gilbert, J. Pharm. Pharmacol. , 1981, 33, 8P.
  • " Metabolic C- and N-Oxidation, and N-Methylation of [2-14C]Pyridine In Vivo: Determination of Urinary Metabolites by HPLC " . By Mahmoud S. Shaker, Peter A. Crooks and Lyaquatali A. Damani, J. Pharm. Pharmacol. , 1981, 33,10P.
  • " Alpha-Adrenoceptor Properties of Some Dihydroxybenzonorbornenes Designed as Rigid Catecholamines " . By Peter Burn, Peter A. Crooks, Christopher Waldron and Peter E. Hicks, J. Pharm. Pharmacol. , 1981, 33, 83P.
  • " Sympathomimetic Effects of Exo- and Endo-isomers of 2-Aminobenzonorbornene In Vitro and In Vivo " . By Peter Burn, Peter A. Crooks, Brian L. Ratcliffe and John M.H. Rees, J. Pharm. Pharmacol. , 1980, 32, 87-91.
  • " Synthesis and Analgesic Properties of Some Conformationally Restricted Analogues of Profadol " . By Peter A. Crooks and Richard Szyndler, J. Medicin. Chem., 1980, 23(6), 679-682.
  • " Synthesis of 2-Amino-1,3-dihydroxyindanes " . By Peter A. Crooks, Chemistry and Industry (London) , 1980, 467-468.
  • " 5,6- and 6,7-Dihydroxyspiro[tetralin-1,3'-pyrrolidine]: Conformationally Restricted Analogues of Dopamine " . By Peter A. Crooks, Richard Szyndler and Barry Cox, Pharm. Acta Helv. , 1980, 55(5), 134-137.
  • " Stereochemical Course of the Transmethylation Catalysed by Catechol O-Methyltransferase " . By Ronald W. Woodard, Ming-Daw Tsai, Heinz G. Floss, Peter A. Crooks and James K. Coward, J. Biol. Chem., 1980, 255, 9124 -9127.
  • " The Role of Brain 5-Hydroxytryptamine in the Analgesic Action of Centrally Acting Sympathomimetics " . By O.T. Ginarvi, Peter Burn, Peter A. Crooks and John M.H. Rees, J. Pharm. Pharmacol. , 1980, 32, 77P.
  • " Determination of 5-Hydroxytryptamine Metabolites in Isolated Perfused Rabbit Lung by High Performance Liquid Chromatography " . By Peter A. Crooks, Robert N. Dreyer, Christopher H. Sulens, C. Norman Gillis and James K. Coward, Analyt. Biochem. , 1979, 93, 143-152.
  • " Synthesis of 5-Hydroxy- and 5,6-Dihydroxy- derivatives of Spiro[indan-2,2'-pyrrolidine], Rigid Analogues of Tyramine and Dopamine Respectively " . By Peter A. Crooks and Howard E. Rosenberg, J. Chem. Soc.,Perkin Trans. I, 1979, 11, 2719-2726.
  • " In Vitro and In Vivo Effects of S-Tubercidinylhomocysteine - A Physiologically Stable Methylase Inhibitor " . By James K. Coward and Peter A. Crooks, Transmethylation, 1979, 5, 215-224.
  • " Metabolism of S-Adenosylhomocysteine and S-Tubercidinylhomocysteine in Neuroblastoma Cells " . By Peter A. Crooks, Robert N. Dreyer and James K. Coward, Biochemistry, 1979, 18, 2601-2610.
  • " The Synthesis and In Vitro Pharmacological Evaluation of Some Novel Enkephalin Analogues " . By Trevor Deeks, Peter A. Crooks and Roger D. Waigh, J. Pharm. Pharmacol. , 1979, 31, 62P.
  • " High-Performance Liquid-Chromatographic Method for the Determination of In Vitro Metabolites of Metyrapone. " By Lyaquatali A. Damani, Peter A. Crooks and John W. Gorrod, J. Pharm. Pharmacol., 1979, 31, 95P.
  • " A Carbon-13 NMR Study of Benzonorbornene Isomers " . By Peter K. Burn, Peter A. Crooks and Otto Meth-Cohn, Org. Magnet. Resonance. , 1978, 11, 370-372.
  • " Synthesis of Spiro[tetralin-2,2'-pyrrolidine] and Spiro[indan-2,2'-pyrrolidine] Derivatives as Potential Analgesics " . By Peter A. Crooks and Howard E. Rosenberg, J. Medicin. Chem., 1978, 21, 585-587.
  • " Extensive Conjugation of Dopamine (3,4-Dihydroxyphenethylamine) Metabolites in Cultured Human Skin Fibroblasts and Rat Hepatoma Cells " . By Peter A. Crooks, Xandra O. Breakefield, Christopher H. Sulens, Carmela M. Castiglione and James K. Coward, Biochem. J. , 1978, 176, 187-196.
  • " Catecholamine Metabolism and Drug Effects in Cultured Mammalian Cells:Analysis by HPLC " . By Peter A. Crooks, Xandra O. Breakefield and James K. Coward, Proc. 4th Int. Catecholamine Symp. , 1978, 1, 210-213.
  • " Rearrangement Products from the Reaction of Diphenyltriketone with Ureas " . By Peter A. Crooks, Trevor Deeks and Francesco DeSimone, Chemistry and Industry (London) , 1976, 323 324.
  • " The Intramolecular Condensation of 2-Acylamino-3-hydroxyphenalene-1-ones and Related Compounds:. By Peter A. Crooks, Antonio Dini and Francesco DeSimone, Rend. Acc. Fis. Mat. Napoli, 1976, Seri 4, XLIII, 37-44.
  • " The 13C-Nuclear Magnetic Resonance Spectra of Physostigmine and Relate Compounds " . By Peter A. Crooks, Brian Robinson and Otto Meth-Cohn, Phytochemistry, 1976, 15, 1903-1904.
  • " Synthesis and Antinociceptive Properties of Spiro[indan-2,2'-pyrrolidine], Spiro-[tetralin-2,2' pyrrolidine] and their N-Methyl Derivatives " . By Peter A. Crooks and Howard E. Rosenberg, J. Pharm. Pharmacol. , 1976, 28, 83P.
  • " Rearrangement of the Carbobenzyloxy Group - An Example of an Oxo-Wittig Rearrangement " . By Peter A. Crooks, Ronald H.B. Galt and Zbigniew S. Matusiak, Chemistry and Industry (London) , 1976, 693-694.
  • " Antinociceptive and Sympathomimetic Activities of Exo- and Endo-2-aminobenzonorbornene and their N-Methylated Derivatives " . By Peter Burn, Peter A. Crooks and John M.H. Rees, J. Pharm. Pharmacol. , 1976 28, 80P.
  • " The Structure of Some Reaction Products of 2,3-Dihydrophenalene-1,2,3-trione with Urea and its Homologues " . By Peter A. Crooks, Trevor Deeks and Francesco DeSimone, Gazz. Chim. Ital. , 1976, 107, 353-354.
  • " Reaction of Ninhydrin with N-alkylacetamides " . By Peter A. Crooks, Chemistry and Industry (London) , 1975, 176-177.
  • " Reaction of Ninhydrin with Urea and N-substituted Ureas " . By Peter A. Crooks and Trevor Deeks, Chemistry and Industry (London) , 1975, 793-794.
  • " The Determination of the Hydrophile-Hydrophobe Proton Ratio in a Series Polyoxyethylene Sorbitan esters " . By Peter A. Crooks, John H. Collett and Roger Withington, Pharm. Acta Helv. , 1974, 49, 274-276.
  • " A New Synthesis of 2-Aminoindanes " . By Peter A. Crooks, Chemistry and Industry (London) , 1974, 495.
  • " Conopharyngine pseudoindoxyl, a new Alkaloid from Tabernamontana pachysiphon Stapf. var. cumminsii (Stapf.) H. Huber " . By Peter A. Crooks and Brian Robinson, J. Pharm. Pharmacol. , 1973, 25, 820-823.
  • " Effects of Amphetamine, 2-Aminoindane and 2-Aminotetralin on the Concentration of Whole Brain Noradrenaline, Dopamine, 5-Hydroxytryptamine and 5-Hydroxyindoleacetic Acid in the Mouse " . By Peter A. Crooks, Hilary J. Little and John M.H. Rees, J. Pharm.Pharmacol. , 1973, 25, 124P.
  • " Synthesis of ?-Amino Alcohols via Spiro-Oxiran Intermediates " . By Peter A. Crooks and Richard Szyndler, Chemistry and Industry (London) , 1973, 1111-1112.
  • " The Isolation and Identification of Quininone from Cinchona ledgeriana " . By Peter A. Crooks and Brian Robinson, J. Pharm.Pharmacol., 1970, 22, 469-470.
  • " The Isolation and Identification of Jollyanine from Tabernamontana cumminsii " . By Peter A. Crooks and Brian Robinson, J. Pharm.Pharmacol. 1970, 22, 471-474.
  • " The Isolation and Identification of (-)-Apparicine from Tabernamontana cumminsii " . By Peter A. Crooks and Brian Robinson, J. Pharm. Pharmacol. , 1970, 22, 799-800.
  • " Azaindoles. Part I. The Synthesis of 5-aza- and 5,7-Diazaindoles by the Non-catalytic Thermal Indolisation of 4-Pyridyl- and 4-Pyrimidylhydrazones, respectively " . By Peter A. Crooks and Brian Robinson, Can. J. Chem.,1969, 47, 2061-2067.
  • " Isolation and Structure of an Indole Alkaloid of Biogenetic Interest from Tabernamontana cumminsii " . By Peter A. Crooks, Brian Robinson and George F. Smith, J. Chem. Soc., Chem. Comm. , 1968, 1210.
  • " Thermal Indolisation of 4-Pyrimidylhydrazones and 4-Pyridylhydrazones " . By Peter A. Crooks and Brian Robinson, Chemistry and Industry (London) , 1967, 547-548.
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Book Reviews
  • " Introductory Medicinal Chemistry " , J. B. Taylor, P. D. Kennewell, Halstead Press, New York, 1981. Reviewed by Peter A. Crooks, J. Medicin. Chem., 1983, 26, 458.
  • " Surfactant Systems - Their Chemistry, Pharmacy and Biology " , David Attwood and Andrew T. Florence, Chapman and Hall, New York, 1983. Reviewed by Peter A. Crooks, J. Medicin. Chem. ., 1984, 27, 1754.
  • " Terpenoids and Steroids, Vol.12 Specialist Periodical Reports, Royal Society of Chemistry " , J. R. Hanson, Adlard and Sons, Ltd., 1983. Reviewed by Peter A. Crooks, J. Pharm. Sci. ., 1985, 74, 801-802.
  • " Biosynthesis, Vol. 7 Specialist Periodical Reports, Royal Society of Chemistry " , R. B. Herbert and T. J. Simpson, Adlard and Sons, Ltd., 1983. Reviewed by Peter A. Crooks, J. Pharm. Sci. ., 1985, 74, 702.
  • " Environmental Chemistry, Vol. 3 Specialist Periodical Reports, Royal Society of Chemistry " , H. J. M. Bowen. Whitstable Litho Ltd., 1984. Reviewed by Peter A. Crooks, J. Pharm. Sci. ., 1985, 74, 906-907.
  • " Biological Methylation and Drug Design, " Edit. Ronald T. Borchardt, C.R. Creveling, and P.M. Ueland, Humana Press, Clifton, New Jersey, U.S.A., 1986. Reviewed by Peter A. Crooks, J. Pharm. Sci. ., 1988, 77, 94.
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Patents
  • “Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Same”. By Robert Alonso, Peter A. Crooks, Barry M. Walker, and David R. Worthen, Docket No. Yaupon 2010, Continuation-in-part, Provisional US Patent Application, filed March, 2008.
  • “Use of Lobeline Diastereomers in the Treatment of Central nervous System Diseases, Pathologies, and Drug Abuse”. By Peter A. Crooks, Linda P. Dwoskin, and David R. Worthen, U.S. Provisional Application No. 60/985,189, November 2nd, 2007.
  • “Substituted Arylidenamino Guanidines for Use as Selective NMDA Receptor Inhibitory Modulators”. By Peter A. Crooks, John L. Littleton, Joshua R. Ring, and Sundar Neelakantan, U.S. Patent Application No. 60/884,365, January 10th, 2007.
  • “Compounds Capable of Activating Cholinergic Receptors”. ”. By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Hael Park, Jared M. Wagner, Peter A. Crooks, Patrick M. Lippiello, and Merouane Bencherif, U.S. Patent No. US 7,307,092, December 11th, 2007.
  • “Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents”. By Peter A. Crooks, Craig T. Jordan, and Xiaochen Wei, U.S. Patent No. US7,312,242, December 25th, 2007.
  • “Extraction and Quantitation of Parthenolide from Tanacetum parthenium (Feverfew Plant), Followed by Direct Derivitization to the Antitumor Drug, LC-1”. By Peter A. Crooks and Sundar Neelakantan, U.S. Patent Application, submitted to the University of Kentucky, Intellectual Properties Committee, UK Case No. 1552, December 13th, 2007.
  • “Mono-quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acertylcholine Receptors”. By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng, Sangeetha Sumithran, and Zhenfa Zhang, International Patent No. WO 2007/149392, December 27th, 2007.
  • “Bis-Quaternary Ammonium Salts and methods for Modulating neuronal Nicotinic Acetylcholine Receptors”. By Peter A. Crooks, Linda P. Dwoskin, , Zhenfa, Zheng Guangrong Zheng, and Marharyta Pivavarchyk, International Patent No. WO 2007/149163, December 27th, 2007.
  • “Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Threof”. By Robert Alonso, Peter A. Crooks, Mark A. Pimley, and Stuart R. Lessin, Korean Patent No. KR 2007/01222201163, December 21st, 2007.
  • “tetrakis-Quaternary Ammonium Compounds that Interact with neuronal Nicotinic Receptors”. By Peter A. Crooks, Linda P. Dwoskin, Zheng, Zhenfa, Marharyta Pivavarchyk, submitted to the University of Kentucky Intellectual Properties Office, Case No. 1494, April, 2007.
  • “bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors”. By Peter A. Crooks, Guangrong Zheng, Linda P. Dwoskin, and Sangeetha Sumithran, UK Case No. 1401; filed as a U.S. Utility Patent Application January 12th, 2007.
  • “bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors”. By Peter A. Crooks, Guangrong Zheng, Zhenfa Zhang, Linda P. Dwoskin, Sangeetha Sumithran, and Marharyta Pivavarchyk, UK Case No. 1439; filed as a U.S. Utility Patent Application May 31, 2007.
  • “bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Receptors”. By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng, Zhenfa Zhang, Sangeetha Sumithran, David D. Allen, and Paul Lockman, UK Case No. 1429, Filed as a U.S. Utility Patent Application, May 12th, 2007.
  • “Permeable, Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents with Alkanoic Acids”. By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, and Paul Ashton, U.S. Patent No. US 7,214,710, May 8th, 2007.
  • “Synergistic Combinations of Norketamine and Opiate Analgesics”. By Joseph R. Holtman and Peter A. Crooks, U.S. Patent Application No. US 11/558,782, November 10th, 2007.
  • “Compounds of Use in the Treatment of Epilepsy, Seizure and Electroconvulsant Disorders”. By Peter A. Crooks, Aimee K. Bence, and David R. Worthen, U.S. Patent No. 7,226,949, June 5th, 2007.
  • “Method for Enantioselectively Forming R-(+)-Nornicotine or S-(-)-Nornicotine”.By Marhaba Hojahmat, Xiaochen Wei and Peter A. Crooks, Docket No. Yaup-1960, Filed as a U.S. Provisional Patent, May, 2007.
  • “Synergistic Combinations of Norketamine and Opioid Analgesics”. By Joseph R. Holtman and Peter A. Crooks, International Patent No. WO 2007/059445 A2, May 24th, 2007.
  • “Analgesics and Methods of Use”. By Richard Smith-Carliss, Frank S. Caruso, Peter A. Crooks, Kenneth J. Kellar, and Yingxian Xiao, U.S. Patent Application No. US 2007/0129434 A1, June 7th, 2007.
  • “tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors”. By Peter A. Crooks, Guangrong Zheng, Linda P. Dwoskin, Roger Papke, and Sangeetha Sumithran, International Patent No. WO 2007/076112 A2, July 5th, 2007.
  • “Analgetic Pyrroline Derivatives”. By Yingxian Xiao, Peter A. Crooks, Richard Smith-Carliss, Kenneth J. Kellar, Frank S. Caruso, Australian Patent Application No. AU 2002326806 B, July 19th, 2007.
  • “bis-Quaternary Ammonium Salts and methods for Modulating Neuronal Nicotinic Acetylcholine Receptors”. By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng, and Sangeetha Sumithran, International Patent No. WO 2007/094912, August 23rd, 2007.
  • “Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Threof”. By Robert Alonso, Peter A. Crooks, Mark A. Pimley, and Stuart R. Lessin, European Patent Application No. EP06738150.9-1211, October 19th, 2007.
  • “bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Acetylcholine Receptors”. By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng, Zhenfa Zhang, Sangeetha Sumithran, David D. Allen, and Paul Lockman, UK Case No. 1429, International Patent No. WO 2007/133614, November 22nd, 2007.
  • “Opioid-Norketamine Codrug Combinations for Pain Management”. By Joseph R. Holtman and Peter A. Crooks, U.S. Patent Application, submitted to the University of Kentucky, Intellectual Properties Committee, November 21st, 2007.
  • “Opioid-Nornicotine Codrug Combinations for Pain Management”. By Joseph R. Holtman and Peter A. Crooks, U.S. Patent Application, submitted to the University of Kentucky, Intellectual Properties Committee, November 21st, 2007.
  • “Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Threof”. By Robert Alonso, Peter A. Crooks, Mark A. Pimley, and Stuart R. Lessin, European Patent No. EP1858864, November 28th, 2007.
  • “Use of Substituted (Z)- and (E)-2-(1-Benzyl-1H-indol-3-yl)azabicyclo[2.2.2]octan-3-ols and Related Compounds as Radio-sensitizing Agents with Synergystic Antiangiogenic Properties.” By Peter A. Crooks, Vijayakumar N. R. Sonar, Michael L. Freeman, Sekhar R. Konjeti, and Joseph L. Roti Roti, U.S. Patent Application, submitted to the University of Kentucky, Intellectual Properties Committee, September 5th, 2006, Case no. 1458, filed as a U.S. provisional patent No. US60/878,735, January 5th, 2007.
  • “bis-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors”. By Peter A. Crooks, Guangrong Zheng, Zhenfa Zhang, Linda P. Dwoskin, Sangeetha Sumithran, and Marharyta Pivavarchyk, UK Case No. 1439; U.S. Provisional Patent Application 60/814640, May 31,2007.
  • “Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Threof”. By Robert Alonso, Peter A. Crooks, Mark A. Pimley, and Stuart R. Lessin, Canadian Patent No. CA2600468, September 9th, 2006.
  • “Novel Synergistic Opioid-Cannabinoid Codrug for Pain Management.” By Joseph R. Holtman and Peter A. Crooks (Docket No. 13177N/060236), U.S. Patent Application No. US60,828,960, October 10th, 2006.
  • “Lofexidine Enantiomers for Use as a Treatment for CNS Diseases and Pathologies”. By George A. Digenis, Peter A. Crooks, and Abeer M. Al Ghananeem, U.S. Patent Application No. 11,376,710, filed March 14th, 2006.
  • “Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents”. By Peter A. Crooks, Craig T. Jordan, and Xiaochen Wei, Korean Patent Application No. KR 20060037340, May 3rd, 2006.
  • “Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Hael Park, Jared M. Wagner, and Peter A. Crooks, U.S. Patent Application No. US 2006/0264445 A1, November 23rd, 2006.
  • “Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Hael Park, Jared M. Wagner, and Peter A. Crooks, Patrick M. Lippiello, Merouane Bencherif, U.S. Patent Application No. US 2006/0293289 A1, December 28th, 2006.
  • “Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park,Jared M. Wagner, and Peter A. Crooks, U.S. Patent No. 7,060,826, June 13th, 2006.
  • “Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park,Jared M. Wagner, and Peter A. Crooks, Canadian Patent Application No. CA 2,501,335, April 4th, 2006.
  • "Chain-Modified Pyridino-N-Substituted Nicotine Compounds for Use in the Treatment of CNS Pathologies." By Peter A. Crooks, Linda P. Dwoskin, Rui Xu, and Joshua T. Ayers, U.S. Patent No. US 7,091,357 B2, August 15th, 2006.
  • “Scopolamine Sublingual Spray for the treatment of Motion Sickness.” By Peter A. Crooks, Abeer Al-Ghananeem, and Ahmad H. Malkawi, U.S. Patent Apllication No.US2006/0193784 A1, August 31st, 2006.
  • “Scopolamine Sublingual Spray for the treatment of Motion Sickness.” By Peter A. Crooks, Abeer Al-Ghananeem, and Ahmad H. Malkawi, International Patent Application No. WO 20060937862006, September 8th, 2006.
  • “Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Thereof.” By Robert Alonso, Peter A. Crooks, Mark A. Pimley, and Stuart R. Lessin, U.S. Patent Application No. US2006/0205694 A1, September 14th, 2006.
  • “Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Thereof.” By Robert Alonso, Peter A. Crooks, Mark A. Pimley, and Stuart R. Lessin, International Patent Application No. WO 20060993852006, September 21st, 2006.
  • “Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Thereof.” By Robert Alonso, Peter A. Crooks, Mark A. Pimley, and Stuart R. Lessin, Australian Patent Application No. AU2006223076 September 21st, 2006.
  • “Sublingual Spray for the Treatment of Pain.” By Peter A. Crooks, Abeer Al-Ghananeem, and Ahmad H. Malkawi, International Patent No. WO 2006105205, October 5th, 2006.
  • “Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents”. By Peter A. Crooks, Craig T. Jordan, and Xiaochen Wei, European Patent Application No. EP 1643984, April 4th, 2006.
  • “Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared M. Wagner, and Peter A. Crooks, U.S. Patent No. 7,045,538, May 16th, 2006.
  • “Enhancing Transdermal Delivery of Opioid Antagonists and Antagonists Using Codrugs Linked to Bupropion or Hydroxybupropion” Peter A. Crooks, Audra L. Stinchcomb, Mohamed O. Hamad, and Paul K. Kiptoo, U.S. Patent Application, submitted to the University of Kentucky Intellectual Properties Committee, May 25th, 2006, Case No. 1426 (docket no. 1028750-000274).
  • “bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Receptors” By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng, Zhenfa Zhang, Sangeetha Sumithran, David D. Allen, and Paul Lockman, UK Case No. 1429, U.S. Provisional Patent Application, US 60/799811, May 12th, 2006.
  • “Synergistic Enhancement of Opioid Analgesia Combination with S(-)- and R(+)-Nornicotine”. By Joseph R. Holtman and Peter A. Crooks, U.S. Patent Application, submitted to the University of Kentucky Intellectual Properties Committee, November 17th, 2005. Case No. 1379 filed as a U.S. Provisional Patent No. US 60/xxx,xxx, December 11th, 2006.
  • “R(+)- and S(-)-Nornicotine for the treatment of Pain”. By Joseph R. Holtman, Peter A. Crooks, Linda P. Dwoskin, and Elzbieta P. Wala, U.S. Patent Application, submitted to the University of Kentucky Intellectual Properties Committee, November 17th, 2005. Case No. 1377 filed as a U.S. Provisional Patent No. US 60/859,488, November 17th, 2006.
  • “Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents”. By Peter A. Crooks, Craig T. Jordan, and Xiaochen Wei, European Patent Application No. EP 4,777,849.3-2123, February 2nd, 2006.
  • “bis-Quaternary Ammonium Compounds that Interact with Neuronal Nicotinic Receptors”. By Peter A. Crooks, Guangrong Zheng, Linda P. Dwoskin, and Sangeetha Sumithran, UK Case No. 1401; U.S. Patent Application, US 60/758,622, January 13th, 2006.
  • “Method for Treatment of Cancer”. By Peter A. Crooks and Robert Alonso, U.S. Patent Application No. US2006/0009468, January 12th, 2006.
  • “mono-Quaternary Ammonium Compounds that Interact with Neuronal Nicotinic Receptors”. By Peter A. Crooks, Guangrong Zheng, Zhenfa Zhang, Linda P. Dwoskin, and Sangeetha Sumithran, U.S. Patent Application, US 60/814,423, July 14th, 2006.
  • “Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents”. By Peter A. Crooks, Craig T. Jordan, and Xiaochen Wei, International Patent Application No. WO 2005/007103 A2, January 27th,2005.
  • “Arylsubstituierte Olefinische Amine und ihre Verwendung als Cholinergische Rezeptoragonisten“. By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared M. wagner, Peter A. Crooks, Patrick M. Lippiello, and Merouane Bencherif, German Patent No. DE 69919537T2, August 9th, 2005.
  • “Co-Pharmaka als ein verfarhane des Kontrollierten Arzneimittel Transportes“. By Paul Ashton, Peter A. Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, and Hong Guo, German Patent No. DE 69433818T2, June 16th, 2005.
  • “Derivados de Azatriciclo[3.3.1.1]decano y Composiciones Farmaceuticas que los Contienen" By Peter A. Crooks, Mexican Patent No. MX PA 00009634 A, June 20th, 2005.
  • “Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents”. By Peter A. Crooks, Craig T. Jordan, and Xiaochen Wei, Canadian Patent Application No. CA 2,532,229, January 27th, 2005.
  • “Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents”. By Peter A. Crooks, Craig T. Jordan, and Xiaochen Wei, Australian Patent Application No. AU 2004257696, January 27th, 2005.
  • “Stabilized Compositions of Volatile Alkylating Agents and Methods of Use Thereof”. Peter A. Crooks, and Robert Alonso, U.S. Patent Application, Docket No. YAUPON-4248US1, December, 2005.
  • “Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared M. Wagner, Peter A. Crooks, U.S. Patent Application No. US 2005/0282846 A1, December 22nd, 2005.
  • “Compounds Capable of Activating Cholinergic Receptors”. By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared M. Wagner, Peter A. Crooks, Patrick M. Lippiello, Merouane Bencherif, U.S. Patent No. US 6,979,695 B2, December 27th, 2005.
  • “Novel tris-Quaternary Ammonium Salts that Interact with Neuronal Nicotinic Receptors”. By Peter A. Crooks, Guangrong Zheng, Linda P. Dwoskin, Roger Papke, Sangeetha Sumithran, U.S. Patent Application, US 60/753,970, December 12th, 2005..
  • “Novel Synergistic Opioid-Cannabinoid Codrug Combinations for Pain Management.” By Joseph R. Holtman and Peter A. Crooks, U.S. Patent Application, submitted to the University of Kentucky Intellectual Properties Committee, December 8th, 2005. Case No. 1392.
  • “Synergistic Enhancement of Opioid Analgesia and Attenuation of Opioid Tolerance and Dependence by Combination with Racemic (+/-) Norketamine, S(-)-Norketamine and R(+)-Norketamine”. By Joseph R. Holtman and Peter A. Crooks, U.S. Patent Application, submitted to the University of Kentucky Intellectual Properties Committee, November 17th, 2005. Case No. 1380.
  • “Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents”. By Peter A. Crooks, Craig T. Jordan, and Xiaochen Wei, U.S. Patent Application No. US2005-0272716 A1, December 8th, 2005.
  • " Bis-Pyridino-containing Compounds for Use in the Treatment of CNS Pathologies " . By Peter A. Crooks, Linda P. Dwoskin, Joshua T. Ayers, Vladimir Grinevich, and Sangeetha P. Sumithran, International Patent No. WO 2005066129 A2, July 27th, 2005.
  • " Novel Oral Bioavailable Prodrugs " . By Peter A. Crooks, Mohamed O. Hamad, and Audra L. Stinchcomb, U.S. Patent No. US 2005/154002, July 14th, 2005.
  • " Compounds Capable of Activating Cholinergic Receptors". By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared M. Wagner, Peter A. Crooks, Patrick M. Lippiello, Merouane Bencherif U.S. Patent No. US 2005/5148611, July 7th, 2005.
  • " Compounds Capable of Activating Cholinergic Receptors". By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared M. Wagner, and Peter A. Crooks, U.S. Patent No. US 2005/131034, June 16th, 2005.
  • " Use of 3-(2-Nitrovinyl)- and 3-(2-Nitropropenyl)indoles as Anticancer Agents " . By Peter A. Crooks and Vijayakumar Sonar, U.S. Patent Application, submitted to the University of Kentucky Intellectual Properties Committee, March 29th, 2005.
  • " Use of N’-Indol-3-ylmethylene)- and N-alkyl-N’-benzo[b]thiophen-3 ylmethylene-N-phenylhydrazines as Antitubercular Agents " . By Peter A. Crooks and Vijayakumar Sonar, U.S. Patent Application, submitted to the University of Kentucky Intellectual Properties Committee, March 25th, 2005.
  • " Use of Substituted N’-(1H-Indol-3-ylmethylene)-N-alkyl-N phenylhydrazines as Anticancer Agents " . By Peter A. Crooks and Vijayakumar Sonar, U.S. Patent Application, submitted to the University of Kentucky Intellectual Properties Committee, March 23rd, 2005.
  • " Use of 3-Aryl/Heteroaryl-2-thiophene-3-yl-acrylonitriles as Anticancer Agents " . By Peter A. Crooks and Vijayakumar Sonar, U.S. Patent Application, submitted to the University of Kentucky Intellectual Propertied Committee, March 22nd, 2005.
  • " Sublingual Oxycodone for Acute Pain Management " . By Peter A. Crooks, Abeer M. Al Ghananeem, and Ahmad Malkawi, U.S. Provisional Patent Application, filed March 21st, 2005.
  • " Lofexidine Enantiomers for Use as a Treatment for CNS Diseases and Pathologies " . By George A. Digenis, Peter A. Crooks, and Abeer M. Al Ghananeem, U.S. Patent Application No. US60/661,525, filed March 14th, 2005.
  • " Scopolamine Sublingual Spray for the Treatment of Motion Sickness " . By Peter A. Crooks, Abeer M. Al Ghananeem, and Ahmad Malkawi, U.S. Provisional Patent Application, filed February 10th, 2005.
  • " 2,6-Disubstituted Piperidines for the Treatment of Psychostimulant Abuse and Withdrawal, Eating Disorders, and Central Nervous System Diseases and Pathologies " . By Peter A. Crooks, Linda P. Dwoskin, and Marlon D. Jones, U.S. European Patent No. EP1513513, March 16th, 2005.
  • " Novel Oral Bioavailable prodrugs " . By Peter A. Crooks, Mohamed O. Hamad, and Audra L. Stinchcomb, International Patent No. WO 2005/009377 A2, February 3rd, 2005.
  • " Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents " . By Peter Crooks, Craig T. Jordan, and Xiaochen Wei, U.S. Patent Application No. US 2005/0032886, February 10th, 2005.
  • " Codrugs as a Method of Controlled Drug Delivery " . By Paul Ashton, Peter A. Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, Danish Patent No. DK 740650T, September 27th, 2004. Spanish Patent No. ES 2,222,455T, February 1st, 2005.
  • " Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents " . By Peter Crooks, Craig T. Jordan, and Xiaochen Wei, International Patent No. WO2005007103, January 27th, 2005.
  • " 2,6-Disubstituted Piperidines and Piperazine Compounds " . By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng, Dennis K. Miller, Seth D. Norholm, Krishnan Sairam, and Marlon D. Jones, U.S. Patent No. US2004/266824, December 30th, 2004.
  • " Compounds of Use in the Treatment of Epilepsy, Seizer, and Electroconvulsive Disorders " . By Peter A. Crooks, Aimee K. Bence, and David R. Worthen, U.S. Patent No. US2004/266737, December 30th, 2004.
  • " Analgesic Uses of Norketamine and Ketamine/Norketamine Prodrugs " . By Peter Crooks and Miguel Rivera, U.S. Patent No. US2004/0248964 A1, December 9th, 2004.
  • " Arylsubstituerede Olefiiske Aminer og deres Anvendelse som Cholinerge Receptoragonister " . By Patrick M. Lippiello, Merouane Bencherif, Peter A. Crooks, Jared M. Wagner, Srishailkumar B. Hadimani, Gary M. Dull, Balwinder S. Bhatti, William S. Caldwell, and Haeil Park, Danish Patent No. DK 1,086,082T, November 22nd, 2004.
  • " Compounds Capable of Activating Cholinergic Receptors " . By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared M. Wagner, and Peter A. Crooks, U.S. Patent No. US 2004/214784, October 28th, 2004.
  • " Permeable, Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents with Alkanoic Acids " . By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, and Paul Ashton, U.S. Patent No. US 2004/214784, October 28th, 2004.
  • " Codrugs as a Method of Controlled Drug Delivery " . By Paul Ashton, Peter A. Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, Danish Patent No. DK 740650T, September 27th, 2004.
  • " 3-Pyridyl-1-Aza-Bicyclo-Alkane Derivatives for Prevention and Treatment of CNS Disorders " . By Gary M. Dull, Patrick M. Lippiello, Merouane Bencherif, Balwinder S. Bhatti, William S. Caldwell, and Peter A. Crooks, Spanish Patent No. ES 2,214,707T, September 16th, 2004.
  • " Arylsubstituierte Olefinische Amine und Ihre Verwendung als Cholinergische Rezeptoragonisten " By Patrick M. Lippiello, Merouane Bencherif, Peter A. Crooks, Jared M. Wagner, Srishailkumar B. Hadimani, Gary M. Dull, Balwinder S. Bhatti, William S. Caldwell, and Haeil Park, Austrian Patent No. AT 273,956T, September 15th, 2004.
  • " Aryl Substituted Olefinic Amines and Their Use As Cholinergic Receptor Agonists " . By Patrick M. Lippiello, Merouane Bencherif, Peter A. Crooks, Jared M. Wagner, Srishailkumar B. Hadimani, Gary M. Dull, Balwinder S. Bhatti, William S. Caldwell, and Haeil Park, European Patent No. EP 1,086,082 B1, August 18th, 2004.
  • " Pharmaceutical Compounds and Methods for Use " . By Peter A. Crooks and Naranjan M. Deo, German Patent No. DE 69,910,993T, July 22nd, 2004.
  • " Permeable, Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents with Alkanoic Acids " . By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, and Paul Ashton, U.S. Patent No. US 6,765,019 July 20th, 2004.
  • " Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents. " By Peter A. Crooks, Xiachem Wei and Craig Jordan, U.S. Patent Application No. 10/888,274, July 9th, 2004.
  • " Method for Treatment of Cancer " . By Peter A. Crooks and Robert Alonso, U.S. Patent Application (Docket No. YAUP-3920), filed July 8th, 2004.
  • " Codrugs as a Method of Controlled Drug Delivery " . By Paul Ashton, Peter A. Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, German Patent No. DE 69,433,818D, July 1st, 2004.
  • " Derivados De 3-Piridil-1-aza-biciclo-alcano Para A Prevencao E Tratamento De Desordens Do SNC " . By By Alain Ravard, Balwinder S. Bhatti, Niranjan M. Deo, Patrick M. Lippiello, Peter A. Crooks, William S. Caldwell, Merouane Bencherif, and Gary M. Dull, Portuguese Patent No. PT 994875T, June 30th, 2004.
  • " 3-Pyridyl-1-Aza-Bicyclo-Alkane Derivatives for Prevention and Treatment of CNS Disorders " . By Alain Ravard, Balwinder S. Bhatti, Niranjan M. Deo, Patrick M. Lippiello, Peter A. Crooks, William S. Caldwell, Merouane Bencherif, and Gary M. Dull, Danish Patent No. DK 994,875, June 26th, 2004.
  • " Analgesic Uses of Norketamine and Ketamine/Norketamine Prodrugs " . By Peter Crooks and Miguel Rivera, Australian Patent No. AU 2003,291,037, June 15th, 2004.
  • " Kombinierte Wirkstoffe als Methode Zur Gezieten Wirkstoffe Freisetzung " . By Paul Ashton, Peter A. Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, Austrian Patent No. AT 267,798T, June 15th, 2004.
  • " Analgesic Uses of Norketamine and Ketamine/Norketamine Prodrugs " . By Peter A. Crooks and Miguel Rivera, International Patent No. WO 2004-045601, June 3rd, 2004.
  • " Analgetic Pyrroline Derivatives " . By Richard Smith-Carliss, Frank S. Caruso, Peter Crooks, Kenneth J. Keller, and Yingxian Xiao, European Patent Application No. EP 1420781 A2, May 26th, 2004.
  • " Codrugs as a Method of Controlled Drug Delivery " . By Paul Ashton, Peter A. Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, European Patent No. EP 0,740,650 B1, May 26th, 2004.
  • " 3-Pyridyl-1-Aza-Bicyclo-Alkane Derivatives for Prevention and Treatment of CNS Disorders " . By Alain Ravard, Balwinder S. Bhatti, Niranjan M. Deo, Patrick M. Lippiello, Peter A. Crooks, William S. Caldwell, Merouane Bencherif, and Gary M. Dull, German Patent No. DE 69,822,300D, May 15th, 2004.
  • " Pharmaceutical Compounds and Methods for Use " . By Peter A. Crooks and Naranjan M. Deo, Spanish Patent No. ES 2,205,778T, May 1st, 2004.
  • " Disubstituted Piperidine and Piperazine Compounds " . By Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng, Marlon Jones, Dennis K. Miller, Seth Norrholm, and Sairam Krishnamurthy (Docket No. 64684-024), U.S. Patent Application, filed April 1st, 2004.
  • " 2,6-Disubstituted Piperidines and Piperazine Compounds " . By Peter A. Crooks, Linda P. Dwoskin, Marlon D. Jones, Dennis K. Miller, Seth D. Norholm, Guangrong Zheng, and Sairam Krishamurthy, U.S. Patent Application No. 10/813,647, March 31st, 2004.
  • " 3-Pyridyl-1-Azabicycloalkan-Derivate Zur Behandlung Von ZNS Erkrankungen. " By Niranjan M. Deo, Alain Ravard, William S. Caldwell, Merouane Bencherif, Gary M. Dull, Peter A. Crooks, Patrick M. Lippiello, and Balwinder S. Bhatti, Austrian Patent No. AT 261443T, March 15th, 2004.
  • " 3-Pyridyl-1-Aza-Bicyclo-Alkane Derivatives for Prevention and Treatment of CNS Disorders " . By Alain Ravard, Balwinder S. Bhatti, Niranjan M. Deo, Patrick M. Lippiello, Peter A. Crooks, William S. Caldwell, Merouane Bencherif, and Gary M. Dull, European Patent No. EP 0994,875 B1, March 10th, 2004.
  • " 2,6-disubstituted Piperidines as Modulators of Nicotinic Acetylcholine Receptor Mediated Neurotransmitter Release, Uptake and Storage. " By Peter A. Crooks, Linda P. Dwoskin, Dennis K. Miller, Vladimir P. Grinevich, Seth D. Norrholm, and Guangrong Zheng, U.S. Patent No. US 6,703,406, March 9th, 2004.
  • " Bioactive Peptide-based Probes. " By Clair L. Hicks and Peter A. Crooks (Docket No. 434-286, UKRF Disclosure No. 999), U.S. Patent Application No. 10/795,174, filed March 5th, 2004.
  • " Azatricyclo[3.3.1.1]decane Derivatives and Pharmaceutical Compositions Containing Them. " By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks, Haeil Park, Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, Spanish Patent No. ES 2,199,561T, February 16th, 2004.
  • " Compostos Azatricilicos. " By Peter A. Crooks and Niranjan M. Deo, Portuguese Patent No. PT 1,066,287T, January 30th, 2004.
  • " 2,6-Disubstituted Piperidines as Modulators of Nicotinic Acetylcholine Receptor Mediated Neurotransmitter Release, Uptake and Storage. " By Peter A. Crooks, Linda P. Dwoskin, Dennis K. Miller, Vladimir P. Grinevich, Seth D. Norrholm, and Guangrong Zheng, U.S. Patent Application No. US 2004/0019081 A1, January 29th, 2004.
  • " 2,6-Disubstituted Piperidines as Modulators of Nicotinic Acetylcholine Receptor Mediated Neurotransmitter Release, Uptake and Storage. " By Peter A. Crooks, Linda P. Dwoskin, Dennis K. Miller, Vladimir P. Grinevich, Seth D. Norrholm, and Guangrong Zheng, U.S. Patent Application No. US 2004/006098, January 29th, 2004.
  • " Pharmaceutical Compositions and Methods for Use. " By Peter A. Crooks and Naranjan M. Deo, Danish Patent No. DK 1,066,287T, January 19th, 2004.
  • " Chain-Modified Pyridino-N-Substituted Nicotine Compounds for Use In the Treatment of CNS Pathologies. " By Peter A. Crooks, Linda P. Dwoskin, Rui Xu, and Joshua Ayers, U.S. Patent Application No. US 2003/0225142A1, December 4th, 2003.
  • " Pharmaceutical Compositions and Methods for Use. " By Peter A. Crooks and Naranjan M. Deo, German Patent No. DE 6,991,099D, October 10th, 2003.
  • " Compounds of Use in the Treatment of Epilepsy, Seizure and Electroconvulsive Disorders. " By Peter A. Crooks, Aimee K. Bence, and David R. Worthen, U.S. Patent Application No. US 2003/0,186,942, publication date October 2nd, 2003.
  • " Derivados do Azatriciclo 3.3.1.1 Decano e Composicoes Farmaceuticas Contendo os Mesmos. " By Peter A. Crooks, Haeil Park, and Gary M. Dull, Portuguese Patent No. PT 1,068,208T, September 30th, 2003.
  • " Pharmaceutical Compositions for Treating and/or Preventing CNS Disorders. " By Peter A. Crooks, Gary M. Dull, William S. Caldwell, Balwinder S. Bhatti, Naranjan M. Deo, and Alain Ravard, U.S. Patent No. 6,624,173 B1, September 23rd, 2003.
  • " Azatrizyclische Verbindungen. " By Niranjan M. Deo and Peter A. Crooks, Austrian Patent No. AT 248,839T, September 15th, 2003.
  • " Azatricyclic Compounds " . By Peter A. Crooks and Niranjan M. Deo, European Patent No. EP 1066287 B1, September 3rd, 2003.
  • " Thermal Vaporizing Device for Drug Delivery " . By Peter A. Crooks, S. George Kottayil, Ram Murty and David Riggs, International Patent Application No. WO 02056932 A3, August 7th, 2003.
  • " Opiate Agonist and Antagonist Duplex Prodrugs for Transdermal Delivery " . By Peter A. Crooks, Mohamed O. Hamad, and Audra L. Stinchcomb, UK Disclosure No. 1183, Docket No. 50229-337, filed as a U.S. Provisional Patent Application, No. 60,xxx,xxx, July 23rd, 2003.
  • " Use of Parthenolide Derivatives as Antileukemic and Cytotoxic Agents. " By Peter A. Crooks, Xiachem Wei and Craig Jordan, filed as a Provisional U.S. Patent Application No. 60/486,171, July11th, 2003.
  • " Compounds Capable of Activating Cholinergic Receptors " . By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared M. Wagner, Peter A. Crooks, Patrick M. Lippiello, and Merouane Bencherif, U.S. Patent Application No. 10,263,083 filed October 2nd, 2002. Publication No. US 2003/0125345 A1, Publication Date July 3rd, 2003.
  • " Permeable, Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents with Alkanoic Acids " . By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, and Paul Ashton, Japanese Patent No. JP 2003513884T T, April 15th, 2003.
  • " Cis-2,6-disubstituted Piperidines for the Treatment of Psychostimulant Abuse and Withdrawal, Eating Disorders, and Central Nervous System Diseases and Pathologies. " By Linda P. Dwoskin, Peter A. Crooks, and Marlon D. Jones, U.S. Patent Application, Publication No. US 2003/0100547 A1, Publication date May 29th, 2003.
  • " Azatricyclo[3.3.1.1]decanderivate und Diese Enthaltende Pharmazeutische Zubereitungen " By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks, Haeil Park, Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, Austrian Patent No. AT 24,0331T, May 15th, 2003.
  • " Azatricyclo[3.3.1.1]decane Derivatives and Pharmaceutical Compositions Containing Them. " By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks, Haeil Park, Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, European Patent No. EP 1068208 B1, May 14th, 2003.
  • " Thermal Vaporizing Device for Drug Delivery " . By Peter A. Crooks, S. George Kottayil, Ram Murty and David Riggs, International Patent Application No. WO 02056932 A9, May 1st, 2003.
  • " Analgesics and Methods of Use. " By Richard Smith-Carliss, Frank S. Caruso, Peter Crooks, Kenneth J. Keller, and Yingxian Xiao, International Patent No. WO 03018004 A3, May 22nd, 2003.
  • " Analgesics and Methods of Use. " By Richard Smith-Carliss, Frank S. Caruso, Peter Crooks, Kenneth J. Keller, and Yingxian Xiao, International Patent No. WO 03018004 A2, Publication date March 6th, 2003.
  • " Pharmaceutical Compositions and Methods for Use. " By Jeffrey D. Schmitt, Peter Crooks, and Gary M. Dull, U.S. Patent Application, Publication No. US 2003/0045523 A1, Publication Date March 6th, 2003.
  • " Analgetic Pyrroline Derivatives " . By Richard Smith-Carliss, Frank S. Caruso, Peter Crooks, Kenneth J. Keller, and Yingxian Xiao, Canadian Patent Application No. CA 2,458,015, filed March 3rd, 2003.
  • " Pharmaceutical Compositions and Methods for Effecting Dopamine Release " . By William S. Caldwell, Merouane Bencherif, Gary M. Dull, Peter A. Crooks, and Patrick M. Lippiello, U.S. Patent No. 6,525,065, February 25th, 2003.
  • " Bridged Nicotine Compounds for Use in the Treatment of CNS Pathologies. " By Peter A. Crooks, Linda P. Dwoskin, Rui Xu, and Vladimir P. Grinevich, U.S. Patent No. 6,503,922, January 7th, 2003.
  • " Chain-Modified Pyridino-N-Substituted Nicotine Compounds for Use In the Treatment of CNS Pathologies. " By Peter A. Crooks, Linda P. Dwoskin, Rui Xu, and Joshua Ayers, U.S. Patent Application No. 10/328,192, filed December 26th, 2002.
  • " Analgesic Uses of Norketamine and Ketamine/Norketamine " . By Peter A. Crooks, and Miguel Rivera, U.S. Provisional Application No. 60/426,793, November 18th, 2002.
  • " Lobeline and Other Gag Reflex-Inducing Bitter Alkaloids in Combination with Opioids in Extended Release Formulations to Deter Targeted Chewing by Recreational or Addicted Drug Abusers " . By Richard D. Smith-Carliss and Peter Crooks, to be filed as a U.S. Provisional Patent, October, 2002.
  • " Cis-2,6-disubstituted Piperidines for the Treatment of Psychostimulant Abuse and Withdrawal, Eating Disorders, and Central Nervous System Diseases and Pathologies. " By Linda P. Dwoskin, Peter A. Crooks, and Marlon D. Jones, Australian Patent No. AU 6,386700, September 24th, 2002.
  • " Cis-2,6-disubstituted Piperidines for the Treatment of Psychostimulant Abuse and Withdrawal, Eating Disorders, and Central Nervous System Diseases and Pathologies. " By Linda P. Dwoskin, Peter A. Crooks, and Marlon D. Jones, U.S. Patent No. 6,455,543, September 24th, 2002.
  • " Pharmaceutical Compositions and Methods for Use " . By Jeffrey D. Schmitt, Peter Crooks, and Gary M. Dull, Japanese Patent No. JP 2002531564T T, September 24th, 2002.
  • " Cis-2,6-disubstituted Piperidines for the Treatment of Psychostimulant Abuse and Withdrawal, Eating Disorders, and Central Nervous System Diseases and Pathologies. " By Linda P. Dwoskin, Peter A. Crooks, and Marlon D. Jones, U.S. Patent Application, No. 10/231,156, August 30th, 2002.
  • " Analgesics and Methods of Use " . By Richard Smith-Carliss, Frank S. Caruso, Peter Crooks, Kenneth J. Keller, and Yingxian Xiao, International Patent Application, PCT Serial No. PCT/US/27936, filed August 29th, 2002.
  • " Permeable, Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents with Alkanoic Acids " . By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, and Paul Ashton, European Patent No. EP 1,233,789A August 28th, 2002.
  • " Thermal Vaporizing Device for Drug Delivery " . By Peter A. Crooks, S. George Kottayil, and David Riggs, U.S. Patent Application No. 09/984,294, filed October 29, 2001, Publication No. US 2002/0117175 A1, Publication Date August 29th, 2002.
  • " Prodrugs of Chemotherapeutic Agents with Oxaalkanoic Acids. " By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, and Paul Ashton, European Patent No. EP 1,233,789, August 28th, 2002.
  • " Pharmaceutical Compositions and Methods for Use " . By Jeffrey D. Schmitt, Peter A. Crooks, and Gary M. Dull, U.S. Patent No. 6,432,975, August 13th, 2002.
  • " Analgetic Pyrroline Derivatives " . By Richard Smith-Carliss, Frank S. Caruso, Peter Crooks, Kenneth J. Keller, and Yingxian Xiao, European Patent Application No. EP 02,761,550.9-2123, filed August 29th, 2002. &ldquo Bridged Nicotine Compounds for Use in the Treatment of CNS Pathologies &rdquo . By Peter A. Crooks, Linda P. Dwoskin, Rui Xu, and Vladimir P. Grinevich, U.S. Patent Application No. 09/941,926, filed August 30, 2001, Publication no. US 2002/0099069 A1, Publication Date July 25th, 2002.
  • " Bridged Nicotine Compounds for Use in the Treatment of CNS Pathologies " . By Peter A. Crooks, Linda P. Dwoskin, Rui Xu, and Vladimir P. Grinevich, Australian Patent No. AU 8,687501, July 25th, 2002.
  • " Boron-Containing Nicotine Analogs for Use in the Treatment of CNS Pathologies " . By Peter A. Crooks, Linda P. Dwoskin, Vladimir P. Grinevich, and Rui Xu, International Patent No. WO 02/057275, July 25th, 2002.
  • " Thermal Vaporizing Device for Drug Delivery " . By S. George Kottayil, Peter A. Crooks, David Riggs, and Ram Murty, International Patent No. WO 02/056932, July 25th, 2002.
  • " Pharmaceutical Compositions and Methods for Use " . By Peter A. Crooks, Haeil Park, Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, U.S. Patent No. 6,417, 359, July 9th, 2002.
  • " Aryl Substituted Olefinic Amines and Their Use As Cholinergic Receptor Agonists " . By Patrick M. Lippiello, Merouane Bencherif, Peter A. Crooks, Jared M. Wagner, Srishailkumar B. Hadimani, Gary M. Dull, Balwinder S. Bhatti, William S. Caldwell, and Haeil Park, Japanese Patent No. JP 2002518373T T, June 25th, 2002.
  • " Morphine-6-O-sulfate Analogues and Their Use for the Treatment of Pain " . By Peter Crooks, Abdulghani A. Houdi, Santosh G. Kottayil, and D. Allan Butterfield, U.S. Patent No. 6,403,602, June 11th, 2002.
  • " Cis-2,6-Disubstituted Piperidines as Modulators of Nicotinic Acetylcholine Receptor Mediated Neurotransmitter Release and Neurotransmitter Uptake and Storage " . By Peter A. Crooks, Guangrong Zheng, Dennis K. Miller, Seth Norrholm, Vladimir P. Grinevich, and Linda P. Dwoskin, U.S. Patent Application No. US 10/163,633, June 7th, 2002.
  • " Agmatine and Agmatine Derivatives for Use in the Treatment of Epilepsy, Seizure and Electroconvulsive Disorders " . By Peter A. Crooks, Aimee K. Bence, and David R. Worthen, U.S. Patent Application No. 09/881,215, filed June 15, 2000, Publication No. US 2002/0065323 A1, Pub. Date May 30, 2002.
  • " Compounds Capable of Activating Cholinergic Receptors " . By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared M. Wagner, and Peter A. Crooks, U.S. Patent Application No. 09/973,411, filed October 9, 2001, Publication No. US 2002/0052497 A1, Publication Date, May 2nd, 2002.
  • " Azatricyclo[3.3.1.1]decane Derivatives and Pharmaceutical Compositions Containing Them. " By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks, Haeil Park, Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, Japanese Patent No. JP 2002510690T, April 9th, 2002.
  • " 3-Pyridyl-1-Aza-Bicyclo-Alkane Derivatives for Prevention and Treatment of CNS Disorders " . By Alain Ravard, Balwinder S. Bhatti, Niranjan M. Deo, Patrick M. Lippiello, Peter A. Crooks, William S. Caldwell, Merouane Bencherif, and Gary M. Dull, Japanese Patent No. JP 2002511090, April 9th, 2002.
  • " Pharmaceutical Compositions and Methods for Use. " By Peter A. Crooks and Naranjan M. Deo, Japanese Patent No. JP 2002510689T, April 9th, 2002.
  • " Bridged Nicotine Compounds for Use In the Treatment of CNS Pathologies " . By Peter A. Crooks, Linda P. Dwoskin, Rui Xu, and Vladimir Grinevich, International Patent No. WO 02/17922, March 7, 2002.
  • " Compounds for Use in the Treatment of Epilepsy, Seizure and Electroconvulsive Disorders. " By Peter A. Crooks, Aimee K. Bence, and David R. Worthen, Provisional U.S. Patent No. US 60/348,366, filed January 16th, 2002.
  • " Chain-Modified Pyridino-N-Substituted Nicotine Compounds for Use In the Treatment of CNS Pathologies. " By Peter A. Crooks, Linda P. Dwoskin, Rui Xu, and Joshua Ayers, Provisional U.S. Patent No. US 60/342,120, filed December 26th, 2001.
  • " Agmatine and Agmatine Analogs In the Treatment of Epilepsy, Seizure, and Electroconvulsive Disorders " . By Peter A. Crooks, Aimee K. Bence, and David R. Worthen, International Patent No. WO 01/95897, December 20, 2001.
  • " Prodrugs of Chemotherapeutic Agents with Oxaalkanoic Acids. " By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, and Paul Ashton, European Patent No. EP 928,867, December 12, 2001.
  • " Bis-Pyridino Containing Compounds for Use in the Treatment of CNS Pathologies. " By Peter A. Crooks, Linda P. Dwoskin, and Joshua Ayers, submitted to the Office Of Intellectual Properties, University of Kentucky, November 12th, 2001. (UK Case No. 1101).
  • " Permeable, Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents with Alkanoic Acids " . By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Paul Ashton, and Hong Guo, Canadian Patent No. CA 2,368,831, November 5th, 2001.
  • " Analgesics and Methods of Use " . By Richard Smith-Carliss, Frank S. Caruso, Peter Crooks, Kenneth J. Keller, and Yingxian Xiao, U.S. Patent Application No. 60/315,530, August 29th, 2001.
  • " Permeable Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents with Oxaalkanoic Acids " . By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, and Paul Ashton, International Patent No. WO 0067801 A3, August 2nd, 2001. (Licensed).
  • " Aza-Aminotetralin Compounds for Use in the Treatment of CNS Pathologies. " By Peter A. Crooks, Linda P. Dwoskin, and Rui Xu, submitted to the Office of Intellectual Properties, University of Kentucky, July, 8, 2001. (UK Case No. 1069, Docket No. 50229-281).
  • " Boron-Containing Nicotine Analogs for Use in the Treatment of CNS Pathologies. " By Peter A. Crooks, Linda P. Dwoskin, Rui Xu, Vladimir Grinevich, and Roger L. Papke, (Docket No. 50229-249), U.S. Patent Application No. 60/261,822, May, 2001.
  • " Use of the Naturally Occurring Quinones, Thymoquinone and Dithymoquinone, as Antineoplastic and Cytotoxic Agents " . Peter A. Crooks, David R. Worthen, and Omar Ghosheh. U.S. Patent No. 6,218,434, April 17, 2001.
  • " Pharmaceutical Compositions and Methods for Use " . By Peter A. Crooks and Niranjan M. Deo, U.S. Patent No. 6,211,372, April 3, 2001.
  • " Aminas Olefinicas Substituidas com Arila e o seu uso como Agonistas de Receptores Colinergicos. " By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishalikumar B. Hadimani, Haeil Park, Jared M. Wagner, Peter A. Crooks, Patrick M. Lippiello, and Merouane Bencherif, Brazilian Patent No. BR 9,911,325, April 3, 2001.
  • " Aryl Substituted Olefinic Amines and Their Use As Cholinergic Receptor Agonists " . By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared M. Wagner, Peter A. Crooks, Patrick M. Lippiello, and Merouane Bencherif, European Patent No. EP 1,086,082A1, March 28, 2001.
  • " Cis-2,6-disubstituted Piperidines for the Treatment of Psychostimulant Abuse and Withdrawal, Eating Disorders, and Central Nervous System Diseases and Pathologies. " By Linda P. Dwoskin, Peter A. Crooks, and Marlon D. Jones, International Patent No. WO 108,678A1, February 8, 2001.
  • " Azatricyclo(3.3.1.1)decane Derivatives and Pharmaceutical Compositions Containing Them. " By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks, Haeil Park, Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, European Patent No. EP 1,068,208A1, January 17, 2001.
  • " Azatricyclic Compounds " . By Peter A. Crooks and Niranjan M. Deo, European Patent No. EP 1,066,287A1, January 10, 2001.
  • " Compostos Azatriciclicos " . By Peter A. Crooks and Niranjan M. Deo, Brazilian Patent No. BR 9907191A, December 26th, 2000.
  • " Permeable Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents with Oxaalkanoic Acids " . By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, and Paul Ashton, Australian Patent No. AU 4703700, November 16th, 2000. (Licensed).
  • " Permeable Water Soluble, Non-Irritating Prodrugs of Chemotherapeutic Agents with Oxaalkanoic Acids " . By Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, and Paul Ashton, International Patent No. WO 067,801A2, November 16th, 2000. (Licensed).
  • " Thermal Vaporizing Device for Drug Delivery " . By Peter A. Crooks, S. George Kottayil, and David Riggs, Provisional US Patent Application No. 60/243,404, October 27, 2000.
  • " Derivados de Cabeca de Ponte de Piridila e Seus Analogos, Composicoes Farmaceuticas e Seus Empregos Como Inibidores de Receptores Colinergicos Nicotinicos. " By Jeffrey D. Schmitt, Peter A. Crooks, and Gary M. Dull, Brazilian Patent No. BR 9,907,169, October 17, 2000.
  • " Derivados de Azatriciclo(3.3.1.1)decano e Composicoes Farmaceuticas Contendo-Os. " By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks, Haeil Park, Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, Brazilian Patent No. BR 9,907,172A, October 10, 2000.
  • " Compounds Useful for the Treatment of CNS Pathologies. " By Peter A. Crooks, Linda P. Dwoskin, Rui Xu, and Vladimir Grinevich, (Docket No. 50229-193), U.S. Patent Application No. 60/228,766, August 30th, 2000.
  • " Use of Lobeline Compounds in the Treatment for Central Nervous System Diseases and Pathologies. " By Peter A. Crooks and Linda P. Dwoskin, U.S. Patent No. 6,087,376, July 11, 2000.
  • " Use of Bacteriophage Peptides to Manufacture Markers for Rapid Assays, and for Specific Cell Delivery of Antibiotics. " By Clair L. Hicks and Peter A. Crooks, Submitted to the Office of Intellectual Properties, University of Kentucky (UKRF Case No. 999), September, 2. "Pharmaceutical Compositions and Methods for Use", By Niranjan M. Deo and Peter Crooks, Canadian Patent No. CA 2,317,570, June 29th, 2000., filed as a US provisional patent.
  • " Pyridyl-Bridgehead Derivatives and their Analogs, Pharmaceutical Compositions and their Use as Inhibitors of Nicotinic Cholinergic Receptors " . By Jeffrey D. Schmitt, Peter A. Crooks, and Gary M. Dull, Australian Patent No. AU 5,699,399, June 26th, 2000.
  • " Pyridyl-Bridgehead Derivatives and their Analogues, Pharmaceutical Compositions and Their Use as Inhibitors of Nicotinic Cholinergic Receptors. " By Jeffrey D. Schmitt, Peter A. Crooks, and Gary M. Dull, International Patent No. WO 034,276A1, June 15, 2000.
  • " Codrugs as a Method of Controlled Drug Delivery " . By Paul Ashton, Peter A. Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, Australian Patent No. AU 705,226B2, May 20, 2000.
  • " Agmatine and Agmatine Analogs In the Treatment of Epilepsy, Seizure, and Electroconvulsive Disorders " . By Peter A. Crooks, Aimee K. Bence, and David R. Worthen, Australian Patent No. AU 6,842201, June 15th, 2000. "Pyridyl-Bridgehead Derivatives and their Analogs, Pharmaceutical Compositions and their Use as Inhibitors of Nicotinic Cholinergic Receptors", By Jeffrey D. Schmitt, Peter A. Crooks, and Gary M. Dull, European Patent No. EP 1,053,236, June 15th, 2000. "Certain 1-Aza-tricyclo[3.3.1-13,7]decane Compounds", By Peter A. Crooks, Haeil Park, Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, U.S. Patent, 6,057,446, May 2, 2000.
  • " 3-Pyridyl-1-Aza-Bicyclo-Alkane Derivatives for Prevention and Treatment of CNS Disorders " . William S. Caldwell, Merouane Bencherif, Gary M. Dull, Peter A. Crooks, Patrick M. Lippiello, Balwinder S. Bhatti, Niranjan M. Deo, and Alain Ravard, European Patent EP 994,875A1, April 26, 2000.
  • " Codrugs as a Method of Controlled Drug Delivery " . By Paul Ashton, Peter A. Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, Guo Hong, European Patent EP 740,650A4, April 19, 2000.
  • " Azatricyclo(3.3.1.1)decane Derivatives and Pharmaceutical Compositions Containing Them. " By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks, Haeil Park, Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, Australian Patent No. AU 2,892,999A1, May 2, 2000. &ldquo Means to Achieve Sustained Release of Synergistic Drugs By Conjugation &rdquo . Paul Ashton, Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Robert M. Riggs and Hong Guo, U.S. Patent No. 6,051,576, April 18th, 2000. (Licensed).
  • " Aryl Substituted Olefinic Amines and Their Use As Cholinergic Receptor Agonists " . By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared M. Wagner, Peter A. Crooks, Patrick M. Lippiello, and Merouane Bencherif, Australian Patent No. AU 4,230,799, January 5, 2000.
  • " Aryl Substituted Olefinic Amines and Their Use As Cholinergic Receptor Agonists " . By William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared M. Wagner, Peter A. Crooks, Patrick M. Lippiello, and Merouane Bencherif, International Patent, WO 99/65,876A1, December 23rd, 1999.
  • " Pharmaceutical Compositions and Methods for Effecting Dopamine Release " . By William S. Caldwell, Merouane Bencherif, Gary M. Dull, Peter A. Crooks, Patrick M. Lippiello, Balwinder S. Bhatti, Niranjan M. Deo, and Alain Ravard, Canadian Patent Application, CA 627,206, December 20, 1999.
  • " Azatricyclic Compounds " . By Peter A. Crooks and Niranjan M. Deo, Australian Patent No. AU 2,794,899A1, October 25th, 1999. &ldquo Azatricyclic Compounds. &rdquo By Peter A. Crooks and Niranjan M. Deo, International Patent, WO 99/51,601A1, October 14th, 1999. (Licensed).
  • " Azatricyclo[3.3.1.1]Decane Derivatives and Pharmaceutical Compositions Containing Them. " By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks, Haeil Park, Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, International Patent, WO 99/51,602A1, October 14th, 1999 (licensed).
  • " Azatricyclo[3.3.1.1]decane Derivatives and Pharmaceutical Compositions Containing Them. " By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks, Haeil Park, Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, German Patent No. DE 69,907,894D, October 14th, 1999.
  • " Azatricyclo[3.3.1.1]decane Derivatives and Pharmaceutical Compositions Containing Them. " By Merouane Bencherif, Patrick M. Lippiello, Peter A. Crooks, Haeil Park, Balwinder S. Bhatti, William S. Caldwell, and Gary M. Dull, Danish Patent No. DK 1,068,208T, October 14th, 1999.
  • " Pharmaceutical Compositions and Methods for Use " . By Peter A. Crooks, Haeil Park, Gary M. Dull, Patrick M. Lippiello, Merouane Bencherif, Balwinder S. Bhatti, and William S. Caldwell, Canadian Patent No. CA 2,317,567, October 10th, 1999.
  • " Pharmaceutical Compositions and Methods for Use " . By Peter A. Crooks and Niranjan M. Deo, U.S. Patent No. 5,986,100, November 16, 1999. (Licensed).
  • " Pyridyl-Bridgehead Derivatives and their Analogs, Pharmaceutical Compositions and their Use as Inhibitors of Nicotinic Cholinergic Receptors " . By Gary M. Dull, Jeffrey D. Schmitt, and Peter A. Crooks, Canadian Patent No. CA 2,317,025, August 31, 1999.
  • " Aryl Substituted Olefinic Amines and Their Use As Cholinergic Receptor Agonists " . By Patrick M. Lippiello, Merouane Bencherif, Peter A. Crooks, Jared M. Wagner, Srishailkumar B. Hadimani, Gary M. Dull, Balwinder S. Bhatti, William S. Caldwell, and Haeil Park, Canadian Patent No. CA 2,334,923, June 3, 1999.
  • " Azatricyclo[3.3.1.1]Decane Derivatives and Pharmaceutical Compositions Containing Them. " By Haeil Park, Gary M. Dull, William S. Caldwell, Balwinder S. Bhatti, Patrick M. Lippiello, Peter A. Crooks, and Merouane Bencherif, Canadian Patent No. CA 2,317,567, March 3, 1999.
  • " Azatricyclic Compounds " . By Niranjan M. Deo, and Peter A. Crooks, Canadian Patent No. CA 2,317,570, February 26, 1999.
  • " Compounds Which are Useful for Prevention and Treatment of Central Nervous System Disorders " . By Peter A. Crooks, William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Niranjan M. Deo, Alain Ravard, Japanese Patent No. JP 11501294T, February 2, 1999. (Licensed).
  • " 3-Pyridyl-1-Aza-Bicyclo-Alkane Derivatives for Prevention and Treatment of CNS Disorders " . By William S. Caldwell, Merouane Bencherif, Gary M. Dull, Peter A. Crooks, Patrick M. Lippiello, Balwinder S. Bhatti, Niranjan M. Deo, and Alain Ravard, Australian Patent No. AU 7,149,798A1, January 19, 1999.
  • " Canavanine Analogs and Their Use as Chemotherapeutic Agents " . By Peter A. Crooks and Gerald A. Rosenthal, U.S. Patent No. 5,859,295, January 12, 1999.
  • " 3-Pyridyl-1-azabicycloalkane Derivatives for Prevention and Treatment of CNS Disorders. " By William S. Caldwell, Merouane Bencherif, Gary M. Dull, Peter A. Crooks, Patrick M. Lippiello, Balwinder S. Bhatti, Niranjan M. Deo, and Alain Ravard, International Patent, WO 99/00,385A1, January 7th, 1999. (Licensed).
  • " Lobeline Compounds as a Treatment for Psycho Stimulant Abuse and Withdrawal, and for Eating Disorders ". By Peter A. Crooks and Linda P. Dwoskin, U.S. Patent No. 5,830,904, November 3, 1998. (Licensed)
  • " Nornicotine Enantiomers for Use as a Treatment for Dopamine-Related Conditions and Disease States " . By Peter A. Crooks, Linda P. Dwoskin and Michael T. Bardo, U.S. Patent No. 5,776,957, July 8,1998.
  • " 3-Pyridyl-1-Aza-Bicyclo-Alkane Derivatives for Prevention and Treatment of CNS Disorders " . By Alain Ravard, Balwinder S. Bhatti, Niranjan M. Deo, Patrick M. Lippiello, Peter A. Crooks, William S. Caldwell, Merouane Bencherif, and Gary M. Dull, Canadian Patent No. CA 2,294,990, April 22, 1998.
  • " Pharmaceutical Compositions for Prevention and Treatment of Central Nervous System Disorders ". By Peter A. Crooks, William S. Caldwell, Gary M. Dull, and Balwinder S. Bhatti, European Patent EP 801,646A4, March 25, 1998.
  • " Pharmaceutical Compositions for Prevention and Treatment of Central Nervous System Disorders." By Peter A. Crooks, William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, European Patent No. EP0801646A4, March 25th, 1998. . (Licensed).
  • " Pharmaceutical Compositions for Prevention and Treatment of Central Nervous System Disorders." By Peter A. Crooks, William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Niranjan M. Deo and Alain Ravard, U.S. Patent No. 5,726,316, March 10, 1998.(Licensed).
  • " Nicotinic Receptor Antagonists in the Treatment of Neuropharmacological Disorders". By Peter A. Crooks, Linda P. Dwoskin and Alain Ravard, U.S. Patent No. 5,691,365, November 25, 1997. (Licensed).
  • " Permeable, Non-Irritating Prodrugs of Non-Steroidal and Steroidal Agents " . By Paul Ashton, Thomas J. Smith, Peter G. Glavinos, John D. Conklin, Jr., Peter Anthony Crooks, Robert Mack Riggs, Tadeusz Cynkowski and Grazyna Cynkowska, U.S. Patent No. 5,681,964, October 28, 1997. (Licensed).
  • " Pharmaceutical Compositions for Prevention and Treatment of Central Nervous System Disorders." By Peter A. Crooks, William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, European Patent No. EP0801646A1, October 22, 1997. (Licensed).
  • " Pharmaceutical Compositions for Prevention and Treatment of Central Nervous System Disorders " . By Peter A. Crooks, William S. Caldwell, Gary M. Dull, and Balwinder S. Bhatti, European Patent EP 801,646A1, October 22, 1997.
  • " Codrugs as a Method of Controlled Drug Delivery " . By Paul Ashton, Peter A. Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, and Hong Guo, Japanese Patent No. JP 9,509,151TZ, September 16, 1997. (Licensed).
  • " Compounds Which are Useful for Prevention and Treatment of Central Nervous System Disorders " . By Peter A. Crooks, William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Niranjan M. Deo, Alain Ravard, U.S. Patent No. 5,616,707, April 1, 1997 (Licensed).
  • " Pharmaceutical Compositions for Prevention of Central Nervous System Disorders " . By Peter A. Crooks, William S. Caldwell, Gary M. Dull, and Balwinder S. Bhatti, Australian Patent No. AU 4,645,596A1, July 24, 1996.
  • " Pharmaceutical Compositions for the Prevention and Treatment of Central Nervous System Diseases " . By Peter A. Crooks, William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, International Patent, WO 96/20,929A1, July 11, 1996. (Licensed).
  • " Pharmaceutical Compositions for the Prevention and Treatment of Central Nervous System Disorders " . By Merouane Bencherif, William S. Caldwell, Gary M. Dull, Patrick M. Lippiello, Peter A. Crooks, Balwinder S. Bhatti, Naranjan M. Deo, Alain Ravard, Australian Patent No. AU 5383196, November 29, 1996.(Licensed).
  • " Pharmaceutical Compositions for the Prevention and Treatment of Central Nervous System Diseases " . By Merouane Bencherif, William S. Caldwell, Gary M. Dull, Patrick M. Lippiello, Peter A. Crooks, Balwinder S. Bhatti, Naranjan M. Deo, Alain Ravard, International Patent, WO 96/36,637A1, November 21, 1996. (Licensed).
  • " Preparation of 2-azabicyclo[2.2.1]hept-5-ene and 2-azabicyclo[2.2.2]oct-5-ene; Compounds of Use in Pharmaceutical Compositions for the Prevention and Treatment of Central Nervous System Disorders " . By Merouane Bencherif, William S. Caldwell, Gary M. Dull, Patrick M. Lippiello, Peter A. Crooks, Balwinder S. Bhatti, Niranjan M. Deo, and Alain Ravard, International Patent, WO 96/36637A1, November 21, 1996. (Licensed).
  • " Codrugs as a Method of Controlled Delivery " By Paul Ashton, Peter A. Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, Guo Hong, European Patent EP 740,650A1, November 6, 1996.
  • " Polynucleotide Analogs Based Upon Sulfonate and Sulfonamide Internucleoside Linkages " . John A. Secrist, John A. Montgomery and Peter A. Crooks, U.S. Patent No. 5, 561,225, October 1, 1996.
  • " Use of L-Canavanine as a Chemotherapeutic Agent for the Treatment of Pancreatic Cancer. " By Peter A. Crooks and Gerald A. Rosenthal, U.S. Patent No. 5,552,440, September 3, 1996.
  • " Co-Drugs as a Method of Controlled Drug Delivery " . Paul Ashton, Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Robert M. Riggs, and Hong Guo, European Patent, No. 94-909643.2-2103, February 2, 1996 (Licensed).
  • " Co-Drugs as a Method of Controlled Drug Delivery " . By Paul Ashton, Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Robert M. Riggs, and Hong Guo, Australian Patent No. AU 6,254,594A, August 15th, 1995. (Licensed).
  • " Codrugs as a Method of Controlled Drug Delivery " . By Paul Ashton, Peter A. Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska, Australian Patent No. AU 6,254,4594A1, August 15, 1995.
  • " Co-Drugs as a Method of Controlled Drug Delivery " . Paul Ashton, Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Robert M. Riggs and Hong Guo, International Patent, WO 95/20,567A1, August 3, 1995. (Licensed).
  • " Pharmaceutical Compositions for Prevention and Treatment of Central Nervous System Disorders " . By Peter A. Crooks, William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Niranjan M. Deo, and Alain Ravard, U.S. Patent Application No. 08/437,154, May 17, 1995. (Licensed).
  • " Co-Drugs as a Method of Controlled Drug Delivery " . By Paul Ashton, Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Robert M. Riggs, and Hong Guo, Canadian Patent No. CA 2,182,228AA, February 17, 1994. (Licensed).
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